Department of Immunology, Medical University of Bialystok, Poland.
Department of Immunology, Medical University of Bialystok, Poland.
Mol Cell Endocrinol. 2018 Oct 15;474:238-251. doi: 10.1016/j.mce.2018.03.014. Epub 2018 Mar 27.
Preservatives (ingredients which inhibit growth of microorganisms) are used to prolong shelf life of various foods, cosmetics, and pharmaceutical products. Parabens are one of the most popular preservatives used in the aforementioned products and is currently being used worldwide. Parabens are easily absorbed by the human body. Thus, it is important to discuss about their safety with respect to human physiology. In view of the current literature, which classifies parabens as a group of endocrine disrupting chemicals (EDCs), it seems that the precise assessment of their influence on the human endocrine system is particularly important. Disruption of the endocrine homoeostasis might lead to multidirectional implications causing disruption of fitness and functions of the body. Therefore, in this review article, we aimed to summarize the current literature on properties, occurrence, and metabolism of parabens as well as to present recent progress in knowledge about their influence on the human endocrine system.
防腐剂（抑制微生物生长的成分）用于延长各种食品、化妆品和药物产品的保质期。对羟基苯甲酸酯是上述产品中使用最广泛的防腐剂之一，目前在全球范围内使用。对羟基苯甲酸酯很容易被人体吸收。因此，讨论它们对人体生理学的安全性非常重要。鉴于目前的文献将对羟基苯甲酸酯归类为一组内分泌干扰化学物质（EDCs），似乎特别需要对其对人体内分泌系统的影响进行精确评估。内分泌平衡的破坏可能会导致多方面的影响，从而破坏身体的适应性和功能。因此，在这篇综述文章中，我们旨在总结对羟基苯甲酸酯的性质、存在和代谢的最新文献，并介绍其对人体内分泌系统影响的最新进展。
