Department of Pediatrics, Division of Host-Microbe Systems & Therapeutics, University of California, San Diego, CA, USA.
Center for Microbiome Innovation, University of California, San Diego, CA, USA.
Nat Rev Microbiol. 2018 Jun;16(6):383-390. doi: 10.1038/s41579-018-0004-5.
Microorganisms engage in complex interactions with other organisms and their environment. Recent studies have shown that these interactions are not limited to the exchange of electron donors. Most microorganisms are auxotrophs, thus relying on external nutrients for growth, including the exchange of amino acids and vitamins. Currently, we lack a deeper understanding of auxotrophies in microorganisms and how nutrient requirements differ between different strains and different environments. In this Opinion article, we describe how the study of auxotrophies and nutrient requirements among members of complex communities will enable new insights into community composition and assembly. Understanding this complex network over space and time is crucial for developing strategies to interrogate and shape microbial communities.
微生物与其他生物及其环境之间存在着复杂的相互作用。最近的研究表明，这些相互作用不仅限于电子供体的交换。大多数微生物都是营养缺陷型的，因此依赖于外部营养物质来生长，包括氨基酸和维生素的交换。目前，我们对微生物中的营养缺陷型以及不同菌株和不同环境之间的营养需求差异缺乏更深入的了解。在这篇观点文章中，我们描述了研究复杂群落成员之间的营养缺陷型和营养需求将如何使我们对群落组成和组装有新的认识。理解这种跨越空间和时间的复杂网络对于开发策略来探究和塑造微生物群落至关重要。
