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Ridinilazole-a novel antibiotic for treatment of Clostridium difficile infection.

作者信息

Steinebrunner Niels, Stremmel Wolfgang, Weiss Karl H

机构信息

Department of Gastroenterology and Hepatology, University Hospital Heidelberg, Heidelberg, Germany.

出版信息

J Thorac Dis. 2018 Jan;10(1):118-120. doi: 10.21037/jtd.2017.12.117.

DOI:10.21037/jtd.2017.12.117
PMID:29600036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5863157/
Abstract
摘要

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本文引用的文献

1
Efficacy and safety of ridinilazole compared with vancomycin for the treatment of Clostridium difficile infection: a phase 2, randomised, double-blind, active-controlled, non-inferiority study.利地硝唑与万古霉素治疗艰难梭菌感染的疗效和安全性比较：一项2期随机双盲活性对照非劣效性研究。
Lancet Infect Dis. 2017 Jul;17(7):735-744. doi: 10.1016/S1473-3099(17)30235-9. Epub 2017 Apr 28.
2
Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection.贝洛妥珠单抗预防复发性艰难梭菌感染。
N Engl J Med. 2017 Jan 26;376(4):305-317. doi: 10.1056/NEJMoa1602615.
3
New and emerging therapies for Clostridium difficile infection.艰难梭菌感染的新型及新兴疗法
Curr Opin Infect Dis. 2016 Dec;29(6):546-554. doi: 10.1097/QCO.0000000000000320.
4
Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969), a novel treatment for C. difficile infection.新型艰难梭菌感染治疗药物瑞地那唑（SMT19969）对艰难梭菌毒素产生及细胞形态的影响
J Antimicrob Chemother. 2016 May;71(5):1245-51. doi: 10.1093/jac/dkv498. Epub 2016 Feb 18.
5
Breakthroughs in the treatment and prevention of Clostridium difficile infection.艰难梭菌感染治疗和预防的突破。
Nat Rev Gastroenterol Hepatol. 2016 Mar;13(3):150-60. doi: 10.1038/nrgastro.2015.220. Epub 2016 Feb 10.
6
A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections.一项随机1期研究，旨在调查新型艰难梭菌感染治疗药物SMT19969在健康男性受试者中单次及多次口服给药后的安全性、药代动力学以及对肠道微生物群的影响。
BMC Infect Dis. 2015 Feb 25;15:91. doi: 10.1186/s12879-015-0759-5.
7
Burden of Clostridium difficile infection in the United States.美国艰难梭菌感染的负担
N Engl J Med. 2015 Feb 26;372(9):825-34. doi: 10.1056/NEJMoa1408913.
8
Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection.口服、胶囊化、冷冻粪菌移植治疗复发性艰难梭菌感染。
JAMA. 2014 Nov 5;312(17):1772-8. doi: 10.1001/jama.2014.13875.
9
Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review.艰难梭菌感染复发、并发症及死亡率的危险因素：一项系统评价
PLoS One. 2014 Jun 4;9(6):e98400. doi: 10.1371/journal.pone.0098400. eCollection 2014.
10
Reduced residual gene expression of nuclear factor of activated T cells-regulated genes correlates with the risk of cytomegalovirus infection after liver transplantation.活化T细胞核因子调控基因的残余基因表达降低与肝移植后巨细胞病毒感染风险相关。
Transpl Infect Dis. 2014 Jun;16(3):379-86. doi: 10.1111/tid.12206. Epub 2014 Mar 26.