Liu Xin-Xin, Teng Yu-Fei, Gao Meng, Liang Xi-Da, Yu Yan-Ping, Liu Wu
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100730, China.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100005, China.
Int J Ophthalmol. 2018 Mar 18;11(3):438-444. doi: 10.18240/ijo.2018.03.14. eCollection 2018.
To compare the optic nerve head (ONH) perfusion in both eyes of unilateral idiopathic macular hole (IMH) with normal control group by using optical coherence tomography angiography (OCTA) and investigate its correlationship with the macular blood perfusion.
We performed a prospective and cross-sectional study that included 19 patients with full-thickness unilateral IMH and 24 age- and sex-matched controls. All participants received OCTA test. The ONH perfusion was evaluated by the regions of peripapillary and whole en face (the sum of peripapillary and optic disc). The potential correlationship between ONH and parafovea were implied. All the data were performed using the nonparametric test.
The mean values of ONH presented that normal control >IMH >unaffected eyes. A statistical variation was found between three groups in the region of temporal (=0.007). Vessel density notablely decreased on the layers of superficial, deep and choroid of parafovea region in IMH group. The correlative coefficients showed that respectively whole en face and deep retina: =0.528, peripapillary and deep retina: =0.525, whole en face and choriocapillaries: =0.569, peripapillary and choriocapillaries: =0.504.
Our study demonstrate a reduced ONH vessel density in both eyes of IMH patients and the vessel density of ONH in IMH eyes are positively correlated with both the retina capillary and choriocapillary in parafoveal. The reduction of vessel densities may indicate the hypoperfusion in IMH eyes.
采用光学相干断层扫描血管造影（OCTA）比较单侧特发性黄斑裂孔（IMH）患者双眼的视神经乳头（ONH）灌注情况，并研究其与黄斑区血流灌注的相关性。
我们进行了一项前瞻性横断面研究，纳入19例单侧全层IMH患者和24例年龄及性别匹配的对照组。所有参与者均接受OCTA检查。通过视乳头周围区域和整个表面区域（视乳头周围区域和视盘之和）评估ONH灌注情况。暗示了ONH与黄斑旁区域之间的潜在相关性。所有数据均采用非参数检验。
ONH的平均值显示正常对照组>IMH组>未受影响眼。在颞侧区域三组之间存在统计学差异（=0.007）。IMH组黄斑旁区域表层、深层和脉络膜层的血管密度显著降低。相关系数显示，整个表面区域与深层视网膜分别为：=0.528，视乳头周围区域与深层视网膜为：=0.525，整个表面区域与脉络膜毛细血管为：=0.569，视乳头周围区域与脉络膜毛细血管为：=0.504。
我们的研究表明，IMH患者双眼的ONH血管密度降低，且IMH眼的ONH血管密度与黄斑旁视网膜毛细血管和脉络膜毛细血管均呈正相关。血管密度降低可能表明IMH眼存在低灌注。
