Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".
作者信息
Lareau Caleb A, Clement Kendell, Hsu Jonathan Y, Pattanayak Vikram, Joung J Keith, Aryee Martin J, Pinello Luca
机构信息
Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
出版信息
Nat Methods. 2018 Apr;15(4):238-239. doi: 10.1038/nmeth.4541. Epub 2018 Mar 30.
Abstract
摘要
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本文引用的文献
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Unexpected mutations after CRISPR-Cas9 editing in vivo.体内CRISPR-Cas9编辑后出现的意外突变。
Nat Methods. 2017 May 30;14(6):547-548. doi: 10.1038/nmeth.4293.
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DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.DNA 修复谱分析揭示 Cas9 介导的断裂的非随机结果。
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Off-target mutations are rare in Cas9-modified mice.脱靶突变在经Cas9修饰的小鼠中很少见。
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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases.GUIDE-seq可实现对CRISPR-Cas核酸酶脱靶切割的全基因组分析。
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Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.通过全基因组测序检测到，单个CRISPR-Cas9和TALEN靶向的人类干细胞克隆中脱靶突变的发生率较低。
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