Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Università degli Studi di Udine, 33100 Udine, Italy.
Dipartimento di Agraria-Laboratorio di Entomologia "E. Tremblay", Università degli Studi di Napoli "Federico II", 80055 Portici (Napoli), Italy.
Viruses. 2018 Mar 30;10(4):159. doi: 10.3390/v10040159.
Any attempt to outline a logical framework in which to interpret the honey bee health decline and its contribution to elevated colony losses should recognize the importance of the multifactorial nature of the responsible syndrome and provide a functional model as a basis for defining and testing working hypotheses. We propose that covert infections by deformed wing virus (DWV) represent a sword of Damocles permanently threatening the survival of honey bee colonies and suggest that any factor affecting the honey bee’s antiviral defenses can turn this pathogen into a killer. Here we discuss the available experimental evidence in the framework of a model based on honey bee immune competence as affected by multiple stress factors that is proposed as a conceptual tool for analyzing bee mortality and its underlying mechanisms.
任何试图勾勒出一个逻辑框架来解释蜜蜂健康衰退及其对蜂群高死亡率的影响的尝试，都应该认识到导致这种现象的多因素综合征的重要性，并提供一个功能模型作为定义和检验工作假设的基础。我们提出，畸形翅膀病毒（DWV）的隐性感染代表着一把达摩克利斯之剑，永久威胁着蜜蜂种群的生存，我们还认为，任何影响蜜蜂抗病毒防御能力的因素都可能使这种病原体成为致命杀手。在这里，我们将在一个基于蜜蜂免疫能力的模型框架内讨论现有的实验证据，该模型受到多种应激因素的影响，被提议作为分析蜜蜂死亡率及其潜在机制的概念工具。
