高盐饮食可下调 H. pylori 感染后 MGs 胃黏膜 TFF2 的表达水平。

High salt diet can down-regulate TFF2 expression level in gastric mucosa of MGs after H. pylori infection.

机构信息

Department of Pathology, Shenyang Medical College, No.146, Huanghe North Avenue, Shenyang, Liaoning, China.

出版信息

Microb Pathog. 2018 May;118:316-321. doi: 10.1016/j.micpath.2018.03.047. Epub 2018 Mar 27.

DOI:10.1016/j.micpath.2018.03.047

Abstract

This study aimed to elucidate the effect of Helicobacter pylori (H. pylori) and high salt diet on Trefoil factor 2 (TFF2) expression level of Mongolian gerbils (MGs) gastric mucosa. The results of H. pylori identification and histopathology showed that H. pylori infected MGs model was built successfully. According to the immunohistochemical staining results, 25% (4/16) of H. pylori infected MGs with high salt diet showed high TFF2 expression, which was significantly lower than H. pylori infection group 61% (11/18)(P = 0.045). The results suggested that High salt diet could down-regulated TFF2 expression level of MGs gastric mucosa induced by H. pylori infection.

摘要

本研究旨在阐明幽门螺杆菌（H. pylori）和高盐饮食对蒙古沙土鼠（MGs）胃黏膜三叶因子 2（TFF2）表达水平的影响。H. pylori 鉴定和组织病理学结果表明，成功建立了 H. pylori 感染 MGs 模型。根据免疫组织化学染色结果，25%（4/16）高盐饮食 H. pylori 感染 MGs 显示高 TFF2 表达，明显低于 H. pylori 感染组的 61%（11/18）（P=0.045）。结果表明，高盐饮食可下调 H. pylori 感染诱导的 MGs 胃黏膜 TFF2 表达水平。