Department of General Surgery, The Affiliated Xuzhou Hospital of Nanjing University of Chinese Medicine, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou, 221003, China.
Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
Sci Rep. 2022 Apr 8;12(1):5980. doi: 10.1038/s41598-022-10014-4.
The burdens and trends of gastric cancer are poorly understood, especially in high-prevalence countries. Based on the Global Burden of Disease Study 2019, we analyzed the incidence, death, and possible risk factors of gastric cancer in five Asian countries, in relation to year, age, sex, and sociodemographic index. The annual percentage change was calculated to estimate the trends in age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR). The highest ASIR per 100,000 person-years in 2019 was in Mongolia [44 (95% uncertainty interval (UI), 34 to 55)], while the lowest was in the Democratic People's Republic of Korea (DPRK) [23 (95% UI, 19 to 29)]. The highest ASDR per 100,000 person-years was in Mongolia [46 (95% UI, 37 to 57)], while the lowest was in Japan [14 (95% UI, 12 to 15)]. Despite the increase in the absolute number of cases and deaths from 1990 to 2019, the ASIRs and ASDRs in all five countries decreased with time and improved sociodemographic index but increased with age. Smoking and a high-sodium diet were two possible risk factors for gastric cancer. In 2019, the proportion of age-standardized disability-adjusted life-years attributable to smoking was highest in Japan [23% (95% UI, 19 to 28%)], and the proportions attributable to a high-sodium diet were highest in China [8.8% (95% UI, 0.21 to 33%)], DPRK, and the Republic of Korea. There are substantial variations in the incidence and death of gastric cancer in the five studied Asian countries. This study may be crucial in helping policymakers to make better decisions and allocate appropriate resources.
胃癌的负担和趋势了解甚少，尤其是在高流行国家。基于 2019 年全球疾病负担研究，我们分析了五个亚洲国家胃癌的发病率、死亡率和可能的危险因素，涉及年份、年龄、性别和社会人口学指数。计算了年变化百分比，以估计年龄标准化发病率（ASIR）和年龄标准化死亡率（ASDR）的趋势。2019 年，每 10 万人年发病率最高的是蒙古[44（95%不确定区间（UI），34 至 55）]，而最低的是朝鲜民主主义人民共和国（朝鲜）[23（95% UI，19 至 29）]。每 10 万人年死亡率最高的是蒙古[46（95% UI，37 至 57）]，而最低的是日本[14（95% UI，12 至 15）]。尽管 1990 年至 2019 年病例和死亡人数绝对增加，但所有五个国家的 ASIR 和 ASDR 随着时间的推移而下降，社会人口学指数有所改善，但随着年龄的增长而增加。吸烟和高钠饮食是胃癌的两个可能危险因素。2019 年，归因于吸烟的年龄标准化伤残调整生命年比例最高的是日本[23%（95% UI，19 至 28%）]，归因于高钠饮食的比例最高的是中国[8.8%（95% UI，0.21 至 33%）]、朝鲜和大韩民国。在研究的五个亚洲国家中，胃癌的发病率和死亡率存在很大差异。本研究对于帮助决策者做出更好的决策和分配适当的资源可能至关重要。
