Institute for the Control of Agrochemicals, Ministry of Agriculture, Beijing 100125, China.
Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Science, Beijing 100097, China.
Regul Toxicol Pharmacol. 2018 Jun;95:250-253. doi: 10.1016/j.yrtph.2018.03.023. Epub 2018 Mar 27.
The residue behavior and dietary intake risks of carbosulfan and its metabolites in cucumbers were investigated. A quick and reliable method for determining carbosulfan and its metabolite residues in cucumbers was established using ultrahigh performance liquid chromatography-tandem mass spectrometry. The fortified recoveries ranged from 87.2% to 91.0% with relative standard deviations of 3.2%-8.1%. The dissipation results showed that carbosulfan was transformed into carbofuran and 3-hydroxy carbofuran in cucumbers. The half-life of carbosulfan was 1.5 days, and the half-life of carbofuran was 45 days. The final residues of carbosulfan varied from 0.245 to 0.005 mg/kg and carbofuran varied from 0.123 to 0.008 mg/kg. After a 5-day application period the residues of carbosulfan was 0.113 mg/kg that was below the maximum residue limit set by China (0.2 mg/kg), and the residues of carbofuran was 0.055 mg/kg that was higher than the maximum residue limit set by China (0.02 mg/kg). The risk assessment results indicated that the dietary intake risks of carbosulfan and carbofuran from cucumber consumption were safe for Chinese consumers, but pre-harvest intervals should be strictly recommended for 7 days at the recommended dose to ensure that food quality conforms to the MRL standard. This study provides a method and data for scientifically evaluating dietary intake risks of carbosulfan and its more toxic metabolites.
研究了在黄瓜中硫丹及其代谢物的残留行为和膳食摄入风险。采用超高效液相色谱-串联质谱法建立了一种快速、可靠的测定黄瓜中硫丹及其代谢物残留量的方法。加标回收率为 87.2%-91.0%，相对标准偏差为 3.2%-8.1%。消解结果表明，硫丹在黄瓜中转化为呋喃丹和 3-羟基呋喃丹。硫丹的半衰期为 1.5 天，呋喃丹的半衰期为 45 天。硫丹的最终残留量在 0.245-0.005mg/kg 之间变化，呋喃丹的残留量在 0.123-0.008mg/kg 之间变化。施药 5 天后，硫丹残留量为 0.113mg/kg，低于中国设定的最大残留限量（0.2mg/kg），呋喃丹残留量为 0.055mg/kg，高于中国设定的最大残留限量（0.02mg/kg）。风险评估结果表明，中国消费者从食用黄瓜中摄入硫丹和呋喃丹的风险是安全的，但在推荐剂量下，应严格建议 7 天的休药期，以确保食品质量符合 MRL 标准。本研究为科学评估硫丹及其毒性更大的代谢物的膳食摄入风险提供了方法和数据。
