Mata-Pérez Capilla, Padilla María N, Sánchez-Calvo Beatriz, Begara-Morales Juan C, Valderrama Raquel, Chaki Mounira, Barroso Juan B
Group of Biochemistry and Cell Signalling in Nitric Oxide, Department of Experimental Biology, Centre for Advanced Studies in Olive Grove and Olive Oils, Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain.
Group of Biochemistry and Cell Signalling in Nitric Oxide, Department of Experimental Biology, Centre for Advanced Studies in Olive Grove and Olive Oils, Faculty of Experimental Sciences, Campus Universitario "Las Lagunillas" s/n, University of Jaén, E-23071, Jaén, Spain.
Nitric Oxide. 2018 Mar 27. doi: 10.1016/j.niox.2018.03.011.
Nitro-fatty acids (NO-FAs) are formed from the reaction between nitrogen dioxide (NO) and mono and polyunsaturated fatty acids. Knowledge concerning NO-FAs has significantly increased within a few years ago and the beneficial actions of these species uncovered in animal systems have led to consider them as molecules with therapeutic potential. Based on their nature and structure, NO-FAs have the ability to release nitric oxide (NO) in aqueous environments and the capacity to mediate post-translational modifications (PTM) by nitroalkylation. Recently, based on the potential of these NO-derived molecules in the animal field, the endogenous occurrence of nitrated-derivatives of linolenic acid (NO-Ln) was assessed in plant species. Moreover and through RNA-seq technology, it was shown that NO-Ln can induce a large set of heat-shock proteins (HSPs) and different antioxidant systems suggesting this molecule may launch antioxidant and defence responses in plants. Furthermore, the capacity of this nitro-fatty acid to release NO has also been demonstrated. In view of this background, here we offer an overview on the biological properties described for NO-FAs in plants and the potential of these molecules to be considered new key intermediaries of NO metabolism in the plant field.
硝基脂肪酸（NO-FAs）由二氧化氮（NO）与单不饱和脂肪酸和多不饱和脂肪酸反应形成。在过去几年里，人们对NO-FAs的了解显著增加，这些物质在动物系统中发现的有益作用促使人们将它们视为具有治疗潜力的分子。基于其性质和结构，NO-FAs能够在水性环境中释放一氧化氮（NO），并具有通过硝基烷基化介导翻译后修饰（PTM）的能力。最近，基于这些源自NO的分子在动物领域的潜力，人们评估了植物物种中亚麻酸硝化衍生物（NO-Ln）的内源性存在。此外，通过RNA测序技术表明，NO-Ln可以诱导大量热休克蛋白（HSPs）和不同的抗氧化系统，这表明该分子可能在植物中引发抗氧化和防御反应。此外，这种硝基脂肪酸释放NO的能力也得到了证实。鉴于此背景，我们在此概述了植物中描述的NO-FAs的生物学特性，以及这些分子被视为植物领域NO代谢新关键中间体的潜力。
