Department of Otolaryngology, University of Kansas Medical Center, Kansas City, Kansas.
Department of Surgery, University of Kansas Medical Center, Kansas City, Kansas.
Cancer Prev Res (Phila). 2018 Aug;11(8):441-450. doi: 10.1158/1940-6207.CAPR-17-0419. Epub 2018 Mar 30.
Head and neck squamous cell carcinoma (HNSCC) accounts for 300,000 deaths per year worldwide, and overall survival rates have shown little improvement over the past three decades. Current treatment methods including surgery, chemotherapy, and radiotherapy leave patients with secondary morbidities. Thus, treatment of HNSCC may benefit from exploration of natural compounds as chemopreventive agents. With excellent safety profiles, reduced toxicities, antioxidant properties, and general acceptance for use as dietary supplements, natural compounds are viewed as a desirable area of investigation for chemoprevention. Though most of the field is early in development, numerous studies display the potential utility of natural compounds against HNSCC. These compounds face additional challenges such as low bioavailability for systemic delivery, potential toxicities when consumed in pharmacologic doses, and acquired resistance. However, novel delivery vehicles and synthetic analogues have shown to overcome some of these challenges. This review covers 11 promising natural compounds in the chemoprevention of HNSCC including vitamin A, curcumin, isothiocyanate, green tea, luteolin, resveratrol, genistein, lycopene, bitter melon, withaferin A, and guggulsterone. The review discusses the therapeutic potential and associated challenges of these agents in the chemopreventive efforts against HNSCC. .
头颈部鳞状细胞癌（HNSCC）每年导致全球 30 万人死亡，在过去的三十年中，总体生存率几乎没有提高。目前的治疗方法包括手术、化疗和放疗，这些方法会给患者带来继发性疾病。因此，探索天然化合物作为化学预防剂可能对头颈部鳞状细胞癌的治疗有益。天然化合物具有良好的安全性、降低毒性、抗氧化特性以及被普遍接受作为膳食补充剂的特点，因此被视为化学预防的一个理想研究领域。虽然该领域的大部分研究仍处于早期阶段，但许多研究显示出天然化合物在预防头颈部鳞状细胞癌方面的潜在应用价值。这些化合物面临着一些额外的挑战，如全身给药时的生物利用度低、在药理剂量下使用时的潜在毒性以及获得性耐药性。然而，新型给药载体和合成类似物已被证明可以克服其中的一些挑战。本综述涵盖了 11 种在预防头颈部鳞状细胞癌方面具有前景的天然化合物，包括维生素 A、姜黄素、异硫氰酸盐、绿茶、木樨草素、白藜芦醇、染料木黄酮、番茄红素、苦瓜、醉茄素 A 和古卡斯特酮。本综述讨论了这些药物在预防头颈部鳞状细胞癌方面的治疗潜力和相关挑战。
