Liew Yoon Xuan, Karen-Ng Lee Peng, Vincent-Chong Vui King
Oral Cancer Research & Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia.
Department of Oral Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
Biomedicines. 2023 Aug 23;11(9):2359. doi: 10.3390/biomedicines11092359.
Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that arises from the epithelium lining of the oral cavity, hypopharynx, oropharynx, and larynx. Despite the advancement of current treatments, including surgery, chemotherapy, and radiotherapy, the overall survival rate of patients afflicted with HNSCC remains poor. The reasons for these poor outcomes are due to late diagnoses and patient-acquired resistance to treatment. Natural products have been extensively explored as a safer and more acceptable alternative therapy to the current treatments, with numerous studies displaying their potential against HNSCC. This review highlights preclinical studies in the past 5 years involving natural products against HNSCC and explores the signaling pathways altered by these products. This review also addresses challenges and future directions of natural products as chemotherapeutic and chemoprevention agents against HNSCC.
头颈部鳞状细胞癌（HNSCC）是一种起源于口腔、下咽、口咽和喉部上皮衬里的癌症。尽管目前的治疗方法不断进步，包括手术、化疗和放疗，但患有HNSCC的患者的总体生存率仍然很低。这些不良结果的原因是诊断延迟和患者获得性治疗耐药性。天然产物已被广泛探索作为当前治疗的一种更安全、更可接受的替代疗法，大量研究显示了它们对HNSCC的潜力。这篇综述重点介绍了过去5年中涉及天然产物抗HNSCC的临床前研究，并探讨了这些产物改变的信号通路。这篇综述还讨论了天然产物作为抗HNSCC的化疗和化学预防剂所面临的挑战和未来方向。
