Masugata Hisashi, Senda Shoichi, Inukai Michio, Himoto Takashi, Hosomi Naohisa, Okada Hiroki, Goda Fuminori
Department of Integrated Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551, Japan.
Exp Ther Med. 2014 Jul;8(1):21-24. doi: 10.3892/etm.2014.1692. Epub 2014 Apr 25.
The present study aimed to investigate the association between plasma brain natriuretic peptide (BNP) levels and systolic blood pressure (SBP) variability over a one-year period. Blood pressure was measured in 44 patients treated for hypertension (73±9 years old) at an outpatient clinic every one to two months over a one-year period. The standard deviation (SD) and the coefficient of variation (CV) were calculated to assess SBP variability. Mean SBP was also calculated over the year. Plasma BNP levels were measured at the end of the one-year period. BNP was found to correlate with mean SBP (r=0.599; P<0.001). However, BNP was not observed to be correlate with either the SD (r=0.219; P=0.153) or the CV (r=0.058; P=0.709) of the SBP. Multiple regression analysis revealed that only the mean values of SBP were independently associated with BNP (β=0.613; P<0.001). Thus, BNP was found to be correlated with mean SBP, but not SBP variability. In conclusion, plasma BNP levels may reflect the average SBP, but not SBP variability over the one-year period prior to the measurement of BNP in patients with hypertension.
本研究旨在调查一年内血浆脑钠肽（BNP）水平与收缩压（SBP）变异性之间的关联。在一年时间里，每1至2个月在门诊对44例高血压患者（73±9岁）测量血压。计算标准差（SD）和变异系数（CV）以评估SBP变异性。还计算了全年的平均SBP。在一年期结束时测量血浆BNP水平。发现BNP与平均SBP相关（r = 0.599；P <0.001）。然而，未观察到BNP与SBP的SD（r = 0.219；P = 0.153）或CV（r = 0.058；P = 0.709）相关。多元回归分析显示，只有SBP的平均值与BNP独立相关（β= 0.613；P <0.001）。因此，发现BNP与平均SBP相关，但与SBP变异性无关。总之，在高血压患者中，血浆BNP水平可能反映测量BNP前一年的平均SBP，但不能反映SBP变异性。
