低血糖所致伴有可逆性胼胝体压部病变的失写症
Agraphia with reversible splenial corpus callosum lesion caused by hypoglycemia.
作者信息
Miyakawa Yukari, Fuchigami Tatsuo, Aoki Masako, Mine Yusuke, Suzuki Junichi, Urakami Tatsuhiko, Takahashi Shori
机构信息
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Brain Dev. 2018 Aug;40(7):592-595. doi: 10.1016/j.braindev.2018.03.003. Epub 2018 Mar 30.
BACKGROUND
Neurological manifestations caused by hypoglycemia range from reversible focal deficits and transient encephalopathy to irreversible coma or death. Recently, high signal intensity lesions in the splenium of the corpus callosum on diffusion-weighted magnetic resonance imaging were reported in adults experiencing hypoglycemia. However, patients presenting with agraphia are rare.
SUBJECT AND METHODS
We examined a 17-year-old left-handed female patient with type 1 diabetes who exhibited transient left agraphia with a reversible splenium lesion of the corpus callosum on diffusion-weighted imaging caused by hypoglycemia, which was improved with blood glucose management alone.
CONCLUSION
This rare case indicates that agraphia, a sign of callosal disconnection syndrome, can result from a reversible splenial lesion of the corpus callosum caused by hypoglycemia.
背景
低血糖引起的神经学表现范围从可逆性局灶性缺损和短暂性脑病到不可逆性昏迷或死亡。最近，有报道称，在经历低血糖的成年人中，扩散加权磁共振成像显示胼胝体压部出现高信号强度病变。然而，出现失写症的患者较为罕见。
对象与方法
我们检查了一名17岁的1型糖尿病左利手女性患者，该患者因低血糖在扩散加权成像上出现胼胝体压部可逆性病变，并伴有短暂性左侧失写症，仅通过血糖管理病情就得到了改善。
结论
这个罕见病例表明，失写症作为胼胝体离断综合征的一种表现，可能由低血糖导致的胼胝体压部可逆性病变引起。
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