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本文引用的文献

1
Pericardial Effusions: Causes, Diagnosis, and Management.心包积液：病因、诊断与处理
Prog Cardiovasc Dis. 2017 Jan-Feb;59(4):380-388. doi: 10.1016/j.pcad.2016.12.009. Epub 2017 Jan 4.
2
Tuberculosis and the Heart.结核病与心脏
Cardiol Clin. 2017 Feb;35(1):135-144. doi: 10.1016/j.ccl.2016.08.007.
3
Advances in the diagnosis of tuberculous pleuritis.结核性胸膜炎的诊断进展。
Ann Transl Med. 2016 Aug;4(15):282. doi: 10.21037/atm.2016.07.23.
4
Diagnostic accuracy of adenosine deaminase for tuberculous pericarditis: a meta-analysis.腺苷脱氨酶对结核性心包炎的诊断准确性：一项荟萃分析。
Eur Rev Med Pharmacol Sci. 2015 Nov;19(22):4411-8.
5
Global epidemiology of tuberculosis.全球结核病流行病学
Cold Spring Harb Perspect Med. 2014 Oct 30;5(2):a017798. doi: 10.1101/cshperspect.a017798.
6
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study.在高负担环境下，与腺苷脱氨酶和未刺激的干扰素-γ相比，定量聚合酶链反应（Xpert MTB/RIF）对结核性心包炎的诊断准确性：一项前瞻性研究。
BMC Med. 2014 Jun 18;12:101. doi: 10.1186/1741-7015-12-101.
7
Diagnostic value of interferon-gamma assay in tuberculosis pericardial effusions: study on a cohort of Iranian patients.干扰素-γ检测在结核性心包积液中的诊断价值：对一组伊朗患者的研究
Acta Med Iran. 2013 Aug 7;51(7):449-53.
8
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies.QUADAS-2：用于诊断准确性研究质量评估的修订工具。
Ann Intern Med. 2011 Oct 18;155(8):529-36. doi: 10.7326/0003-4819-155-8-201110180-00009.
9
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.系统评价与Meta分析的首选报告项目：PRISMA声明
Int J Surg. 2010;8(5):336-41. doi: 10.1016/j.ijsu.2010.02.007. Epub 2010 Feb 18.
10
Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa.撒哈拉以南非洲地区结核性心包炎患者的死亡率
S Afr Med J. 2008 Jan;98(1):36-40.

干扰素-γ在结核性心包炎心包积液诊断中的准确性：一项荟萃分析。

Diagnostic accuracy of interferon-gamma in pericardial effusions for tuberculous pericarditis: a meta-analysis.

作者信息

Liu Chao, Cui Yun-Liang, Ding Chun-Mei, Wu Yan-Hua, Li Hui-Li, Liu Xiao-Fei, Hu Zhi-De

机构信息

Department of Blood Transfusion, General Hospital of Ji'nan Military Region of PLA, Ji'nan 250031, China.

Department of Critical Care Medicine, General Hospital of Ji'nan Military Region of PLA, Ji'nan 250031, China.

出版信息

J Thorac Dis. 2018 Feb;10(2):854-860. doi: 10.21037/jtd.2017.12.107.

DOI:10.21037/jtd.2017.12.107
PMID:29607157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5864581/
Abstract

BACKGROUND

Several studies have investigated the diagnostic accuracy of tests of pericardial effusion interferon-gamma for tuberculous pericarditis in patients with pericardial effusion, but the results have varied. The aim of this study was to investigate the diagnostic accuracy of interferon-gamma for tuberculous pericarditis using meta-analysis.

METHODS

The PubMed and EMBASE databases were searched to identify studies investigating the diagnostic accuracy of tests for interferon-gamma in pericardial effusion for tuberculous pericarditis. The quality of eligible studies was assessed by the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2), and the sensitivities and specificities of interferon-gamma across eligible studies were pooled by a bivariate model.

RESULTS

A total of four studies encompassing 488 subjects were included. The pooled sensitivity, specificity, positive and negative likelihood ratios (NLRs) were 0.97 [95% confidence interval (CI): 0.87-0.99], 0.99 (95% CI: 0.74-1.00), 187 (95% CI: 3-12,542) and 0.03 (95% CI: 0.01-0.14), respectively.

CONCLUSION

Testing for interferon-gamma in cases of pericardial effusion is adequate for identifying or ruling out tuberculous pericarditis.

摘要

背景

多项研究探讨了心包积液中干扰素-γ检测对结核性心包炎的诊断准确性，但结果各异。本研究旨在通过荟萃分析探讨干扰素-γ对结核性心包炎的诊断准确性。

方法

检索PubMed和EMBASE数据库，以确定研究心包积液中干扰素-γ检测对结核性心包炎诊断准确性的研究。采用修订后的诊断准确性研究质量评估（QUADAS-2）对纳入研究的质量进行评估，并通过双变量模型汇总纳入研究中干扰素-γ的敏感性和特异性。

结果

共纳入4项研究，涉及488名受试者。汇总的敏感性、特异性、阳性似然比和阴性似然比分别为0.97[95%置信区间（CI）：0.87-0.99]、0.99（95%CI：0.74-1.00）、187（95%CI：3-12,542）和0.03（95%CI：0.01-0.14）。

结论

在心包积液病例中检测干扰素-γ足以识别或排除结核性心包炎。