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本文引用的文献

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Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.免疫疗法毒性管理：ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2017 Jul 1;28(suppl_4):iv119-iv142. doi: 10.1093/annonc/mdx225.
2
The Why, what, and How of the New FACT standards for immune effector cells.新的免疫效应细胞 FACT 标准的由来、内容和方法。
J Immunother Cancer. 2017 Apr 18;5:36. doi: 10.1186/s40425-017-0239-0. eCollection 2017.
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Indicators of responsiveness to immune checkpoint inhibitors.免疫检查点抑制剂的反应指标。
Sci Rep. 2017 Apr 11;7(1):807. doi: 10.1038/s41598-017-01000-2.
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Reviving the guardian of the genome: Small molecule activators of p53.唤醒基因组的守护者：p53 的小分子激活剂。
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Cytokine Release Syndrome: Inpatient Care for Side Effects of CAR T-Cell Therapy
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Clin J Oncol Nurs. 2017 Apr 1;21(2 Suppl):29-34. doi: 10.1188/17.CJON.S2.29-34.
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Genetics. 2015 Apr;199(4):887-96. doi: 10.1534/genetics.114.173492.

靶向治疗：使用分子和免疫靶向药物对抗癌症。

Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents.

作者信息

Wilkes Gail M

机构信息

Oncology Nursing Consultant, Kilauea, HI, USA.

出版信息

Asia Pac J Oncol Nurs. 2018 Apr-Jun;5(2):137-155. doi: 10.4103/apjon.apjon_79_17.

DOI:10.4103/apjon.apjon_79_17
PMID:29607374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5863423/
Abstract

Today, personalized cancer therapy with targeted agents has taken center stage, and offers individualized treatment to many. As the mysteries of the genes in a cell's DNA and their specific proteins are defined, advances in the understanding of cancer gene mutations and how cancer evades the immune system have been made. This article provides a basic and simplified understanding of the available (Food and Drug Administration- approved) molecularly and immunologically targeted agents in the USA. Other agents may be available in Asia, and throughout the USA and the world, many more agents are being studied. Nursing implications for drug classes are reviewed.

摘要

如今，使用靶向药物的个性化癌症治疗已成为核心，并为许多人提供了个体化治疗。随着细胞DNA中基因及其特定蛋白质的奥秘被揭开，在癌症基因突变以及癌症如何逃避免疫系统的理解方面取得了进展。本文提供了对美国现有（美国食品药品监督管理局批准的）分子靶向和免疫靶向药物的基本且简化的理解。亚洲可能有其他药物，在美国乃至全世界，还有更多药物正在研究中。本文还综述了各类药物的护理注意事项。