Angle Orthod. 2018 Jul;88(4):474-482. doi: 10.2319/112017-801.1. Epub 2018 Apr 2.
To investigate the influence of lithium chloride (LiCl) on orthodontic tooth movement (OTM), orthodontically induced root resorption (OIRR), and bone morphometry.
Ten-week-old female Sprague Dawley rats (n = 32) were divided into four groups based on the concentration of LiCl administered daily per kilogram body weight: 0 (control group), 0.32, 0.64, and 1.28 mM/kg body weight. The maxillary left first molars were moved mesially by a 10 cN coil spring for 14 days. Micro-computed tomography, scanning electron microscope, and scanning laser microscope images were taken to measure the amount of OTM, the volume of OIRR, and bone morphometry.
OIRR clearly decreased depending on the amount of LiCl administered, although OTM moderately decreased. The tooth inclined mesially and the root apex moved distally in the control and 0.32 mM groups. On the other hand, the tooth inclination angle became smaller and the root apex moved mesially in the 0.64 and 1.28 mM groups. In bone morphometry, the cortical bone mineral content and bone volume increased because of LiCl administration, and the trabecular bone measurements decreased. OIRR negatively correlated to the cortical bone measurements, and the amount of OTM significantly correlated to the cortical bone morphometry.
In rats, LiCl reduced OIRR, which induced mesial movement of the tooth root apex. OIRR positively correlated to cortical bone morphometry.
研究氯化锂（LiCl）对正畸牙齿移动（OTM）、正畸诱导根吸收（OIRR）和骨形态计量学的影响。
将 10 周龄雌性 Sprague Dawley 大鼠（n = 32）分为 4 组，根据每天每千克体重给予的 LiCl 浓度进行分组：0（对照组）、0.32、0.64 和 1.28 mM/kg 体重。用 10 cN 线圈弹簧将左侧上颌第一磨牙向近中移动 14 天。通过微计算机断层扫描、扫描电子显微镜和扫描激光显微镜图像来测量 OTM 量、OIRR 体积和骨形态计量学。
OIRR 明显减少，这与给予的 LiCl 量有关，尽管 OTM 适度减少。在对照组和 0.32 mM 组中，牙齿向近中倾斜，根尖向远中移动。另一方面，在 0.64 和 1.28 mM 组中，牙齿倾斜角度变小，根尖向近中移动。在骨形态计量学中，由于 LiCl 的给予，皮质骨矿物质含量和骨体积增加，而小梁骨测量值减少。OIRR 与皮质骨测量值呈负相关，而 OTM 量与皮质骨形态计量学显著相关。
在大鼠中，LiCl 减少了 OIRR，导致牙根根尖向近中移动。OIRR 与皮质骨形态计量学呈正相关。
