State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Arch Oral Biol. 2020 Oct;118:104840. doi: 10.1016/j.archoralbio.2020.104840. Epub 2020 Jul 18.
Estrogen is an essential regulator of the bone tissue. The remodeling of the alveolar bone and periodontal ligament is the basis of orthodontic tooth movement (OTM). There is a negative coregulation between physiological estrogen levels and the rate of OTM. As a possible inhibitory factor of OTM, estrogen suppresses bone resorption by inhibiting osteoclastic differentiation and restraining osteoclast lifespan though multiple pathways and cytokines, leading to the suppression of the initiation step of bone remodeling. On the other hand, estrogen stimulates osteoblastic differentiation and function. Estrogen receptor-α (ERα) involves in the osteogenic responses to mechanical stimulation, and the ERα expression is regulated positively by the levels of circulatory estrogen. Orthodontically induced root resorption (OIRR) is a common side-effect of orthodontic treatment. Estrogen may have some inhibitory effects on OIRR, but more studies are needed to get an effective conclusion.
雌激素是骨组织的重要调节因子。牙槽骨和牙周韧带的改建是正畸牙齿移动（OTM）的基础。生理雌激素水平与 OTM 速度之间存在负协同调节。雌激素作为 OTM 的一种可能抑制因子，通过多种途径和细胞因子抑制破骨细胞分化和延长破骨细胞寿命，从而抑制骨重建的起始步骤，从而抑制骨吸收。另一方面，雌激素刺激成骨细胞分化和功能。雌激素受体-α（ERα）参与机械刺激引起的成骨反应，循环雌激素水平正向调节 ERα 的表达。正畸性根吸收（OIRR）是正畸治疗的常见副作用。雌激素可能对 OIRR 有一定的抑制作用，但需要更多的研究来得出有效的结论。
