Gru Alejandro A, Dehner Louis P
1 Department of Pathology, University of Virginia, Charlottesville, Virginia.
2 Lauren V. Ackerman Laboratory of Surgical Pathology, St. Louis Children's Hospital and Dermatopathology, Washington University Medical Center, St. Louis, Missouri.
Pediatr Dev Pathol. 2018 Mar-Apr;21(2):208-251. doi: 10.1177/1093526617750947.
This article focuses on cutaneous hematopoietic neoplasms that are more likely to be encountered in the pediatric age-group and includes both lymphoproliferative and histiocytic disorders. The cutaneous hematologic disorders in children have a different epidemiologic profile to what is seen during adulthood. Although mycosis fungoides is the most frequent form of cutaneous lymphoma in adults, it is very rare in children. Because lymphoblastic leukemias and lymphomas are more frequent in the pediatric setting, cutaneous leukemic infiltrates are relatively common in this age-group. Similarly, histiocytic disorders are more common in children, particularly Langerhans cell histiocytosis and juvenile xanthogranuloma. Notably, the histiocytic disorders have undergone significant modifications on their nomenclature in the basis of the molecular characteristics that are present in them. A summary of the most frequent cutaneous hematopoietic disorders in children will be discussed further in this review.
本文聚焦于儿童年龄组中更易遇到的皮肤造血系统肿瘤，包括淋巴增殖性疾病和组织细胞疾病。儿童皮肤血液系统疾病的流行病学特征与成人所见不同。虽然蕈样肉芽肿是成人中最常见的皮肤淋巴瘤形式，但在儿童中非常罕见。由于淋巴细胞白血病和淋巴瘤在儿童中更为常见，皮肤白血病浸润在该年龄组相对常见。同样，组织细胞疾病在儿童中更常见，尤其是朗格汉斯细胞组织细胞增多症和幼年性黄色肉芽肿。值得注意的是，基于其中存在的分子特征，组织细胞疾病在命名上有了显著修改。本文将进一步讨论儿童中最常见的皮肤造血系统疾病的总结。
