Gusenbauer Markus, Tóthová Renáta, Mazza Giulia, Brandl Martin, Schrefl Thomas, Jančigová Iveta, Cimrák Ivan
Department for Integrated Sensor Systems, Danube University Krems, Krems an der Donau, Austria.
Department of Software Technologies, University of Žilina, Žilina, Slovakia.
Artif Organs. 2018 Jul;42(7):746-755. doi: 10.1111/aor.13111. Epub 2018 Apr 2.
Shear-induced hemolysis is a major concern in the design and optimization of blood-contacting devices. Even with a small amount of mechanical stress, inflammatory reactions can be triggered in the cells. Blood damage is typically estimated using continuum fluid dynamics simulations. In this study, we report a novel cell damage index (CDI) obtained by simulations on the single-cell level in a lattice Boltzmann fluid flow. The change of the cell surface area gives important information on mechanical stress of individual cells as well as for whole blood. We are using predefined basic channel designs to analyze and compare the newly developed CDI to the conventional blood damage calculations in very weak shear stress scenarios. The CDI can incorporate both volume fraction and channel geometry information into a single quantitative value for the characterization of flow in artificial chambers.
剪切诱导的溶血是血液接触装置设计和优化中的一个主要问题。即使是少量的机械应力，也会在细胞中引发炎症反应。血液损伤通常使用连续介质流体动力学模拟来估计。在本研究中，我们报告了一种通过在格子玻尔兹曼流体流动的单细胞水平上进行模拟获得的新型细胞损伤指数（CDI）。细胞表面积的变化提供了关于单个细胞以及全血机械应力的重要信息。我们正在使用预定义的基本通道设计，在非常弱的剪切应力场景下分析新开发的CDI并将其与传统的血液损伤计算进行比较。CDI可以将体积分数和通道几何信息纳入一个单一的定量值，以表征人工腔室中的流动。
