UMR 782 GMPA, AgroParisTech, INRA, Université Paris Saclay, 78850 Thiverval-Grignon, France.
Biotechnol Adv. 2018 Jul-Aug;36(4):1207-1222. doi: 10.1016/j.biotechadv.2018.03.020. Epub 2018 Mar 31.
Due to concerns about the unsustainability and predictable shortage of fossil feedstocks, research efforts are currently being made to develop new processes for production of commodities using alternative feedstocks. 3-Hydroxypropionic acid (CAS 503-66-2) was recognised by the US Department of Energy as one of the most promising value-added chemicals that can be obtained from biomass. This article aims at reviewing the various strategies implemented thus far for 3-hydroxypropionic acid bioproduction. Special attention is given here to process engineering issues. The variety of possible metabolic pathways is also described in order to highlight how process design can be guided by their understanding. The most recent advances are described here in order to draw up a panorama of microbial 3-hydroxypropionic acid production: best performances to date, remaining hurdles and foreseeable developments. Important milestones have been achieved, and process metrics are getting closer to commercial relevance. New strategies are continuously being developed that involve new microbial strains, new technologies, or new carbon sources in order to overcome the various hurdles inherent to the different microbial routes.
由于担心化石原料的不可持续性和可预见的短缺，目前正在研究使用替代原料生产大宗商品的新工艺。美国能源部已将 3-羟基丙酸（CAS 503-66-2）确认为最有前途的可从生物质获得的高附加值化学品之一。本文旨在综述迄今为止用于 3-羟基丙酸生物生产的各种策略。特别关注工艺工程问题。还描述了可能的多种代谢途径，以突出如何通过了解这些途径来指导工艺设计。本文描述了最新进展，以勾勒出微生物 3-羟基丙酸生产的全景：迄今为止的最佳性能、剩余的障碍和可预见的发展。已经取得了重要的里程碑，并且工艺指标越来越接近商业相关性。为了克服不同微生物途径固有的各种障碍，正在不断开发新的策略，包括新的微生物菌株、新技术或新的碳源。
