Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (MOE), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
Molecules. 2023 Feb 16;28(4):1888. doi: 10.3390/molecules28041888.
3-Hydroxypropionic acid (3-HP) is a platform chemical with a wide range of existing and potential applications, including the production of poly(3-hydroxypropionate) (P-3HP), a biodegradable plastic. The microbial synthesis of 3-HP has attracted significant attention in recent years due to its green and sustainable properties. In this paper, we provide an overview of the microbial synthesis of 3-HP from four major aspects, including the main 3-HP biosynthesis pathways and chassis strains used for the construction of microbial cell factories, the major carbon sources used for 3-HP production, and fermentation processes. Recent advances in the biosynthesis of 3-HP and related metabolic engineering strategies are also summarized. Finally, this article provides insights into the future direction of 3-HP biosynthesis.
3-羟基丙酸（3-HP）是一种具有广泛应用前景的平台化学品，可用于生产聚（3-羟基丙酸）（P-3HP）等可生物降解塑料。由于其绿色环保和可持续性，微生物合成 3-HP 近年来受到了广泛关注。本文从四个主要方面综述了微生物合成 3-HP 的研究进展，包括主要的 3-HP 生物合成途径和底盘菌株用于构建微生物细胞工厂、用于 3-HP 生产的主要碳源以及发酵工艺。此外，还总结了 3-HP 生物合成及相关代谢工程策略的最新进展。最后，本文对 3-HP 生物合成的未来发展方向进行了展望。
