Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA.
Neurobiol Aging. 2018 Jul;67:1-9. doi: 10.1016/j.neurobiolaging.2018.03.004. Epub 2018 Mar 8.
Negative fateful life events (FLEs) such as interpersonal conflict, death in the family, financial hardship, and serious medical emergencies can act as allostatic stressors that accelerate biological aging. However, the relationship between FLEs and neuroanatomical aging is not well understood. We examined 359 men (mean age 62 years) participating in the Vietnam Era twin study of aging (VETSA) to determine whether negative midlife FLEs are associated with advanced brain aging after controlling for physical, psychological, and lifestyle factors. At two different time points, participants were assessed for negative FLEs, health and well-being, general cognitive ability, socioeconomic status, depression, and ethnicity. Participants underwent a magnetic resonance imaging examination, and T1-weighted images were processed with FreeSurfer. Subsequent neuroanatomical measurements were entered into the Brain-Age Regression Analysis and Computation Utility software (BARACUS) to predict brain age. Having more midlife FLEs, particularly relating to interpersonal relationships, was associated with advanced predicted brain aging (i.e., higher predicted brain age relative to chronological age). This association remained after controlling for the significant covariates of alcohol consumption, cardiovascular risk, adult socioeconomic status, and ethnicity.
负面的重大生活事件（FLEs），如人际冲突、家庭死亡、经济困难和严重的医疗紧急情况，可能会成为加速生物衰老的应激源。然而，FLEs 与神经解剖学衰老之间的关系尚不清楚。我们研究了 359 名参与越南时代衰老双胞胎研究（VETSA）的男性（平均年龄 62 岁），以确定在控制身体、心理和生活方式因素后，负面中年 FLEs 是否与大脑老化加速有关。在两个不同的时间点，参与者接受了负面 FLEs、健康和幸福感、一般认知能力、社会经济地位、抑郁和种族的评估。参与者接受了磁共振成像检查，并用 FreeSurfer 处理 T1 加权图像。随后的神经解剖学测量值被输入到 Brain-Age Regression Analysis and Computation Utility 软件（BARACUS）中，以预测大脑年龄。中年时经历更多的 FLEs，特别是与人际关系有关的 FLEs，与预测的大脑老化加速有关（即，相对于实际年龄，预测的大脑年龄更高）。在控制饮酒、心血管风险、成年社会经济地位和种族等重要协变量后，这种关联仍然存在。
