School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia; Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia; Australian Research Council Centre of Excellence for Integrative Brain Function, Clayton, Victoria, Australia.
Neurobiol Aging. 2022 Jan;109:195-203. doi: 10.1016/j.neurobiolaging.2021.10.007. Epub 2021 Oct 20.
Brain age is a neuroimaging-based biomarker of aging. This study examined whether the difference between brain age and chronological age (brain-PAD) is associated with cognitive function at baseline and longitudinally. Participants were relatively healthy, predominantly white community-dwelling older adults (n = 531, aged ≥70 years), with high educational attainment (61% ≥12 years) and socioeconomic status (59% ≥75th percentile). Brain age was estimated from T1-weighted magnetic resonance images using an algorithm by Cole et al., 2018. After controlling for age, gender, education, depression and body mass index, brain-PAD was negatively associated with psychomotor speed (Symbol Digit Modalities Test) at baseline (Bonferroni p < 0.006), but was not associated with baseline verbal fluency (Controlled Oral Word Association Test), delayed recall (Hopkins Learning Test Revised), or general cognitive status (Mini-Mental State Examination). Baseline brain-PAD was not associated with 3-year change in cognition (Bonferroni p > 0.006). These findings indicate that even in relatively healthy older people, accelerated brain aging is associated with worse psychomotor speed, but future longitudinal research into changes in brain-PAD is needed.
脑龄是一种基于神经影像学的衰老生物标志物。本研究探讨了脑龄与实际年龄（脑龄与实际年龄的差值，即 brain-PAD）之间的差异是否与基线和纵向认知功能相关。参与者为相对健康、以白人为主、居住在社区的老年人（n=531，年龄≥70 岁），具有较高的教育程度（61%≥12 年）和社会经济地位（59%≥75%分位数）。脑龄通过 Cole 等人 2018 年开发的算法，从 T1 加权磁共振图像中估算得出。在控制年龄、性别、教育程度、抑郁和体重指数后，brain-PAD 与基线时的运动速度（符号数字模态测试）呈负相关（Bonferroni p<0.006），但与基线时的语言流畅性（受控口头单词联想测试）、延迟回忆（霍普金斯学习测试修订版）或一般认知状态（简易精神状态检查）无关。基线时的 brain-PAD 与 3 年内认知变化无关（Bonferroni p>0.006）。这些发现表明，即使在相对健康的老年人中，大脑衰老加速也与运动速度下降有关，但需要进一步开展关于 brain-PAD 变化的纵向研究。
