Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Sheikh Ahmed Pancreatic Cancer Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Discov. 2018 Apr;8(4):386-388. doi: 10.1158/2159-8290.CD-18-0123.
Development of pancreatic cancer in spontaneous murine models is associated with enrichment of specific strains of gut and intratumoral bacteria that induce a tolerogenic immunosuppressive microenvironment favoring cancer progression and resistance to immunotherapies. Ablation of the microbiome with antibiotics reshapes the tumor microenvironment, inducing T-cell activation, improving immune surveillance, and increasing sensitivity to immunotherapy in established tumors. .
自发性小鼠模型中胰腺癌的发展与肠道和肿瘤内特定菌株的富集有关，这些菌株会诱导免疫耐受的免疫抑制微环境，有利于癌症的进展和对免疫疗法的耐药性。抗生素对微生物组的消融重塑了肿瘤微环境，诱导 T 细胞激活，改善免疫监测，并增加了已建立的肿瘤对免疫疗法的敏感性。
