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成瘾的计算形式是经济价值的选择性倍增。

The computational form of craving is a selective multiplication of economic value.

机构信息

Center for Neural Science, New York University, New York, NY 10003;

Center for Neural Science, New York University, New York, NY 10003.

出版信息

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4122-4127. doi: 10.1073/pnas.1714443115. Epub 2018 Apr 2.

DOI:10.1073/pnas.1714443115
PMID:29610355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5910816/
Abstract

Craving is thought to be a specific desire state that biases choice toward the desired object, be it chocolate or drugs. A vast majority of people report having experienced craving of some kind. In its pathological form craving contributes to health outcomes in addiction and obesity. Yet despite its ubiquity and clinical relevance we still lack a basic neurocomputational understanding of craving. Here, using an instantaneous measure of subjective valuation and selective cue exposure, we identify a behavioral signature of a food craving-like state and advance a computational framework for understanding how this state might transform valuation to bias choice. We find desire induced by exposure to a specific high-calorie, high-fat/sugar snack good is expressed in subjects' momentary willingness to pay for this good. This effect is selective but not exclusive to the exposed good; rather, we find it generalizes to nonexposed goods in proportion to their subjective attribute similarity to the exposed ones. A second manipulation of reward size (number of snack units available for purchase) further suggested that a multiplicative gain mechanism supports the transformation of valuation during laboratory craving. These findings help explain how real-world food craving can result in behaviors inconsistent with preferences expressed in the absence of craving and open a path for the computational modeling of craving-like phenomena using a simple and repeatable experimental tool for assessing subjective states in economic terms.

摘要

cravings 被认为是一种特定的欲望状态,它会使人们偏向于自己想要的东西,无论是巧克力还是毒品。绝大多数人都报告说经历过某种形式的 cravings。在其病理性形式中, cravings 会导致成瘾和肥胖等健康问题。然而,尽管它无处不在且具有临床相关性,但我们仍然缺乏对 cravings 的基本神经计算理解。在这里,我们使用即时的主观估值测量和选择性线索暴露,来识别出类似于食物 cravings 的状态的行为特征,并提出了一个计算框架来理解这种状态如何改变估值以影响选择。我们发现,暴露于特定的高热量、高脂肪/高糖零食会引起受试者对这种零食的即时购买意愿。这种效应是选择性的,但不是专门针对暴露的零食;相反,我们发现它会推广到非暴露的零食,与暴露的零食在主观属性上的相似程度成正比。对奖励大小(可购买的零食数量)的第二次操纵进一步表明,乘法增益机制支持在实验室 cravings 期间估值的转换。这些发现有助于解释为什么现实生活中的食物 cravings 会导致与没有 cravings 时表达的偏好不一致的行为,并为使用简单且可重复的实验工具评估经济方面的主观状态来对类似 cravings 的现象进行计算建模开辟了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/3f3d27ac3760/pnas.1714443115fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/c4002ffc0b05/pnas.1714443115fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/684c8a72e739/pnas.1714443115fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/ddcbf209da43/pnas.1714443115fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/3f3d27ac3760/pnas.1714443115fig04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/c4002ffc0b05/pnas.1714443115fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/684c8a72e739/pnas.1714443115fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/ddcbf209da43/pnas.1714443115fig03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/5910816/3f3d27ac3760/pnas.1714443115fig04.jpg

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