Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110
Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110.
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3817-E3826. doi: 10.1073/pnas.1718267115. Epub 2018 Apr 2.
We often orient to where we are about to reach. Spatial and temporal correlations in eye and arm movements may depend on the posterior parietal cortex (PPC). Spatial representations of saccade and reach goals preferentially activate cells in the lateral intraparietal area (LIP) and the parietal reach region (PRR), respectively. With unimanual reaches, eye and arm movement patterns are highly stereotyped. This makes it difficult to study the neural circuits involved in coordination. Here, we employ bimanual reaching to two different targets. Animals naturally make a saccade first to one target and then the other, resulting in different patterns of limb-gaze coordination on different trials. Remarkably, neither LIP nor PRR cells code which target the eyes will move to first. These results suggest that the parietal cortex plays at best only a permissive role in some aspects of eye-hand coordination and makes the role of LIP in saccade generation unclear.
我们经常确定我们即将到达的位置。眼动和手臂运动的空间和时间相关性可能取决于顶后皮质（PPC）。扫视和到达目标的空间表示分别优先激活外侧顶内区（LIP）和顶前区（PRR）中的细胞。在单臂伸展中，眼动和手臂运动模式高度刻板。这使得研究协调涉及的神经回路变得困难。在这里，我们采用双手伸展到两个不同的目标。动物自然首先向一个目标扫视，然后向另一个目标扫视，从而在不同的试验中产生不同的肢体注视协调模式。值得注意的是，LIP 或 PRR 细胞都不编码眼睛将首先移动到哪个目标。这些结果表明，顶皮质在眼手协调的某些方面最多只起允许作用，并使 LIP 在扫视产生中的作用变得不清楚。
