Eroglu Atilla, Aydin Yener, Yilmaz Omer
Department of Thoracic Surgery, Medical Faculty, Ataturk University, Erzurum, Turkey.
Department of Gastroenterology, Medical Faculty, Ataturk University, Erzurum, Turkey.
Ann Transl Med. 2018 Feb;6(3):40. doi: 10.21037/atm.2017.04.25.
Esophageal perforation may occur spontaneously, iatrogenically or in connection with traumas. Sepsis may develop in connection with mediastinal and pleural exposure in a very short time as a consequence of disintegration of the esophagus. Esophageal perforation is an emergency accompanied with a high level of mortality and morbidity. Rate of mortality for the perforations in the thoracic region is higher than that in the cervical and abdominal regions. Delay in diagnosis and treatment is the most important factor to affect the mortality. A quick and true diagnosis of esophageal perforation is prerequisite for a successful treatment. There is no certain consensus in relation with the optimal treatment of that life-threatening condition. However, in the event that perforation is detected early in a healthy esophagus, then primary repair is recommended. When it is detected late, nonoperative conservative treatment would be appropriate. The rates of mortality for the operations following a period of 24 h after rupture formation are higher than 50%. Esophagectomy is a type of an operation that is to be considered in the event of an end stage benign esophageal disease or of a large esophageal damage that does not allow primary repair. Significant decrease has been observed in the morbidity and mortality of esophageal perforation due to the improvements in the endoscopical techniques today. Minimally invasive techniques, in which drug eluting stents come first, will become an important step for the treatment of esophageal perforations in the forthcoming years.
食管穿孔可自发发生、医源性发生或与外伤有关。由于食管破裂,败血症可能在很短时间内与纵隔和胸膜暴露相关联而发展。食管穿孔是一种伴有高死亡率和发病率的急症。胸段穿孔的死亡率高于颈段和腹段。诊断和治疗的延迟是影响死亡率的最重要因素。快速准确地诊断食管穿孔是成功治疗的前提。对于这种危及生命的疾病的最佳治疗方法尚无定论。然而,如果在健康食管中早期发现穿孔,则建议进行一期修复。如果发现较晚,非手术保守治疗是合适的。破裂形成后24小时后进行手术的死亡率高于50%。食管切除术是在终末期良性食管疾病或食管大面积损伤无法进行一期修复时应考虑的一种手术方式。由于当今内镜技术的改进,食管穿孔的发病率和死亡率已显著降低。以药物洗脱支架为首的微创技术将在未来几年成为治疗食管穿孔的重要一步。