Children's Hospital Vision Center, Akron Children's Hospital, Akron, Ohio, United States.
Department of Ophthalmology, Northeastern Ohio Medical University, Rootstown, Ohio, United States.
Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1760-1768. doi: 10.1167/iovs.17-23229.
This study presents test-retest reliability of optotype visual acuity (OVA) across 60° of horizontal gaze position in patients with infantile nystagmus syndrome (INS). Also, the validity of the metric gaze-dependent functional vision space (GDFVS) is shown in patients with INS.
In experiment 1, OVA was measured twice in seven horizontal gaze positions from 30° left to right in 10° steps in 20 subjects with INS and 14 without INS. Test-retest reliability was assessed using intraclass correlation coefficient (ICC) in each gaze. OVA area under the curve (AUC) was calculated with horizontal eye position on the x-axis, and logMAR visual acuity on the y-axis and then converted to GDFVS. In experiment 2, validity of GDFVS was determined over 40° horizontal gaze by applying the 95% limits of agreement from experiment 1 to pre- and post-treatment GDFVS values from 85 patients with INS.
In experiment 1, test-retest reliability for OVA was high (ICC ≥ 0.88) as the difference in test-retest was on average less than 0.1 logMAR in each gaze position. In experiment 2, as a group, INS subjects had a significant increase (P < 0.001) in the size of their GDFVS that exceeded the 95% limits of agreement found during test-retest.
OVA is a reliable measure in INS patients across 60° of horizontal gaze position. GDFVS is a valid clinical method to be used to quantify OVA as a function of eye position in INS patients. This method captures the dynamic nature of OVA in INS patients and may be a valuable measure to quantify visual function patients with INS, particularly in quantifying change as part of clinical studies.
本研究旨在评估斜视性眼球震颤综合征（INS）患者水平注视 60°范围内视标视力（OVA）的测试-重测信度。同时，还展示了注视相关功能视觉空间（GDFVS）在 INS 患者中的有效性。
在实验 1 中，20 名 INS 患者和 14 名非 INS 患者在 10°步距从左至右 30°范围内的 60 个水平注视位置上各测量两次 OVA。使用各注视位置的组内相关系数（ICC）评估测试-重测信度。在 x 轴上记录水平眼位，y 轴上记录 logMAR 视力，将 OVA 曲线下面积（AUC）绘制出来，再转换为 GDFVS。在实验 2 中，将实验 1 中的 95%一致性界限应用于 85 名 INS 患者治疗前后的 GDFVS 值，以确定 40°水平注视范围内 GDFVS 的有效性。
在实验 1 中，OVA 的测试-重测信度较高（ICC≥0.88），因为在各注视位置上，两次测试的差异平均小于 0.1 logMAR。在实验 2 中，作为一个整体，INS 患者的 GDFVS 显著增大（P<0.001），超出了测试-重测过程中发现的 95%一致性界限。
OVA 是 INS 患者在 60°水平注视范围内可靠的测量方法。GDFVS 是一种有效的临床方法，可用于量化 INS 患者的 OVA 作为眼位的函数。该方法捕捉了 INS 患者 OVA 的动态性质，可能是量化 INS 患者视觉功能的一个有价值的测量方法，特别是在量化临床研究中的变化时。
