Zhang Jing, Zhen Ruiqing, Wei Chunsheng
Department of Facial Plastic Surgery, Eye, Ear, Nose, and Throat Hospital, Fudan University, No. 83, Fenyang Road, Shanghai, 200031, China.
Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, No. 83, Fenyang Road, Shanghai, 200031, China.
Eur Arch Otorhinolaryngol. 2018 Jun;275(6):1525-1532. doi: 10.1007/s00405-018-4957-9. Epub 2018 Apr 2.
The objectives of this study were to observe the regulating effect of KTP laser and Nd:YAG laser in the repair of vocal fold scars.
All rabbits were injured in the muscular layer with a sharp instrument, and then the vocal folds were treated with a KTP laser and a Nd:YAG laser at a power of 2, 4, 6 and 8 W 1 month after the injury. One month after treatment, the rabbits were killed and the throats were removed to detect changes in histology and gene expression of the vocal fold scar after laser therapy.
The best efficacy of all KTP laser treatment groups was the KTP laser 6 W group. Regarding the detection of gene expression, in the KTP laser 6 W and Nd:YAG laser 6 W groups, col-3A1 was decreased compared to the scar group (P < 0.05), and col-1A1 was decreased only in the KTP laser 6 W group (P < 0.05). TGF-β1 levels in the two groups were lower than in the scar group. There were also significant differences in the levels of IL-1β, COX-2 and TNF-α in the two laser groups compared with the scar group (P < 0.05).
KTP laser and Nd:YAG laser treatments for vocal fold scars have particular therapeutic effects. The KTP laser may be better than the Nd:YAG laser for the regulation of vocal fold scars.
NA.
本研究的目的是观察KTP激光和Nd:YAG激光在声带瘢痕修复中的调节作用。
所有兔子均用锐器损伤肌肉层，然后在损伤后1个月用KTP激光和Nd:YAG激光以2、4、6和8W的功率治疗声带。治疗1个月后，处死兔子并取出喉部，以检测激光治疗后声带瘢痕的组织学和基因表达变化。
所有KTP激光治疗组中疗效最佳的是KTP激光6W组。在基因表达检测方面，KTP激光6W组和Nd:YAG激光6W组中，与瘢痕组相比，col-3A1降低（P<0.05），仅KTP激光6W组中col-1A1降低（P<0.05）。两组中的TGF-β1水平均低于瘢痕组。与瘢痕组相比，两个激光组中IL-1β、COX-2和TNF-α水平也有显著差异（P<0.05）。
KTP激光和Nd:YAG激光治疗声带瘢痕有特殊治疗效果。KTP激光在调节声带瘢痕方面可能优于Nd:YAG激光。
无。
