a Key Laboratory for Modern Design & Rotor-Bearing System, Ministry of Education, School of Mechanical Engineering , Xi'an Jiaotong University , Xi'an , P.R. China.
b School of Science , Xi'an Jiaotong University , Xi'an , P.R. China.
J Biomater Sci Polym Ed. 2018 Aug;29(11):1331-1343. doi: 10.1080/09205063.2018.1459351. Epub 2018 Apr 7.
Body fluid is normally the only lubricant after joint replacement surgery, but wear problems have occurred because body fluid has poor lubrication ability. However, traditional lubricant would be diluted by body fluids and then absorbed by the human body. Therefore, an injectable gel with the ability to slow-release lubricant was designed to replace the joint capsule. The proposed gel, poly(ethylene glycol)/chitosan/sodium glycerophosphate (PEG/CS/GP) composite gel was then tested. The tribology results showed that the PEG/CS/GP gel had excellent slow-release properties, especially under pressure, and the PEG played an important role in improving the gel's rheological and mechanical properties. Moreover, this study revealed that the release solution had a good lubrication effect because the PEG and GP could crosslink via the hydrogen bond effect.
体液通常是关节置换手术后唯一的润滑剂，但由于体液的润滑能力差，已经出现了磨损问题。然而，传统的润滑剂会被体液稀释，然后被人体吸收。因此，设计了一种具有缓释润滑剂能力的可注射凝胶来替代关节囊。然后对所提出的聚乙二醇/壳聚糖/甘油磷酸钠（PEG/CS/GP）复合凝胶进行了测试。摩擦学结果表明，PEG/CS/GP 凝胶具有优异的缓释性能，尤其是在压力下，PEG 在改善凝胶的流变和力学性能方面起着重要作用。此外，本研究表明，释放溶液具有良好的润滑效果，因为 PEG 和 GP 可以通过氢键作用交联。
