Lu Hailin, Ren Shanshan, Guo Junde, Li Yue, Li Jianhui, Dong Guangneng
Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System, Xi'an Jiaotong University, Xi'an 710049, PR China.
Department of Chemistry, School of Science, Xi'an Jiaotong University, Xi'an 710049, PR China.
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:239-245. doi: 10.1016/j.msec.2017.03.195. Epub 2017 Mar 22.
Arthroplasty brings the wear problems because of body fluid has poor performance as lubricant. Lubricant which is used in artificial joints will rapidly degrade and be absorbed by human body after injecting. To prolong the lubricant's effectiveness, this study prepared chitosan/poly(ethylene glycol) (CS/PEG) and textures to play a role in joint lubrication and wear protection. Chitosan (CS) and poly(ethylene glycol) which have biocompatibility and biodegradability properties can be used in human body. The tribological results shown that CS/PEG sol has excellent performance when this sol was composed by 2wt% CS and 30wt% PEG, the average friction coefficient below 0.016 under the condition of 30-90N load (pressure 4.2-12.6MPa). In this study, CS/PEG was added in the texture of artificial joints, then the surfaces of the CS/PEG formed gel via NaOH solidification effect. The CS/PEG gel film could prevent the CS/PEG sol from diluting in body fluid. Meanwhile, FT-IR, XRD, UV/vis and Raman spectra revealed that CS associated with PEG via hydrogen bond effect may form a particular structure, which leaded the good tribological performance. This study provides a new, simple and green approach to enhance tribological performances of artificial joints.
由于体液作为润滑剂性能不佳，关节置换术带来了磨损问题。人工关节中使用的润滑剂在注入后会迅速降解并被人体吸收。为了延长润滑剂的有效性，本研究制备了壳聚糖/聚乙二醇（CS/PEG）并使其具有纹理，以在关节润滑和磨损保护中发挥作用。具有生物相容性和生物降解性的壳聚糖（CS）和聚乙二醇可用于人体。摩擦学结果表明，当CS/PEG溶胶由2wt%的CS和30wt%的PEG组成时，其具有优异的性能，在30-90N负载（压力4.2-12.6MPa）条件下平均摩擦系数低于0.016。在本研究中，将CS/PEG添加到人工关节的纹理中，然后CS/PEG的表面通过NaOH固化作用形成凝胶。CS/PEG凝胶膜可以防止CS/PEG溶胶在体液中稀释。同时，傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、紫外可见光谱（UV/vis）和拉曼光谱表明，通过氢键作用与PEG结合的CS可能形成一种特殊结构，这导致了良好的摩擦学性能。本研究提供了一种新的、简单且绿色的方法来提高人工关节的摩擦学性能。
