血浆血管生成生长因子与糖尿病足溃疡的关系。

Relationship between plasma angiogenic growth factors and diabetic foot ulcers.

机构信息

Department of Endocrinology, The Second Affiliated Hospital of Hainan Medical University, HaiKou 570311, Hainan Province, China.

Department of Gerontology, The Hainan General Hospital, HaiKou 570311, Hainan Province, China.

出版信息

Clin Chim Acta. 2018 Jul;482:95-100. doi: 10.1016/j.cca.2018.03.035. Epub 2018 Mar 31.

DOI:10.1016/j.cca.2018.03.035

PMID:29614308

Abstract

BACKGROUND

Angiogenic growth factors play an important role in wound healing. However, their associations with diabetic foot ulcers (DFUs) in humans have rarely been investigated. We examined the relationships between circulating concentrations of vascular endothelial growth factor (VEGF)-A and placenta growth factor (PlGF), and DFU risk.

METHODS

We recruited 447 participants, including 169 DFU patients, 182 diabetes patients without DFUs, and 96 diabetes-free individuals. Plasma VEGF-A and PlGF concentrations were measured using commercial enzyme immunoassay kits.

RESULTS

Concentrations of VEGF-A and PlGF in DFU patients were higher than those in diabetes-free controls (P < 0.05), but lower than those in the diabetic controls (P < 0.05). Increased concentrations of VEGF-A and PlGF were associated with a reduced risk of DFUs. The odds ratios (95% confidence intervals) were 0.93 (0.88, 0.97) for every 10 pg/ml increase in VEGF-A concentrations, and 0.96 (0.94, 0.99) for every 5 pg/ml increase in PlGF concentrations. VEGF-A concentrations were positively related to BMI, glycated hemoglobin (HbA1c), hypertension, and neuropathy, and PlGF was positively correlated to age, HbA1c, and hypertension, among DFU patients.

CONCLUSION

VEGF-A and PlGF play important roles in the development of DFU but need to be confirmed in prospective studies.

摘要

背景

血管生成生长因子在伤口愈合中起着重要作用。然而，它们与人类糖尿病足溃疡（DFU）的关系很少被研究。我们研究了循环血管内皮生长因子（VEGF）-A 和胎盘生长因子（PlGF）浓度与 DFU 风险之间的关系。

方法

我们招募了 447 名参与者，包括 169 名 DFU 患者、182 名无 DFU 的糖尿病患者和 96 名非糖尿病个体。使用商业酶联免疫吸附测定试剂盒测量血浆 VEGF-A 和 PlGF 浓度。

结果

DFU 患者的 VEGF-A 和 PlGF 浓度高于非糖尿病对照组（P<0.05），但低于糖尿病对照组（P<0.05）。VEGF-A 和 PlGF 浓度的增加与 DFU 风险的降低相关。每增加 10pg/ml 的 VEGF-A 浓度，比值比（95%置信区间）为 0.93（0.88，0.97），每增加 5pg/ml 的 PlGF 浓度，比值比为 0.96（0.94，0.99）。VEGF-A 浓度与 BMI、糖化血红蛋白（HbA1c）、高血压和神经病变呈正相关，PlGF 与年龄、HbA1c 和高血压呈正相关。