Pharmaceutical and Healthcare Research Laboratories, Research and Development Management Headquarters, FUJIFILM Corporation, Ashigarakami-gun, Kanagawa, Japan.
Memory Clinic Ochanomizu, Bunkyo-ku, Tokyo, Japan.
J Alzheimers Dis. 2018;62(4):1767-1775. doi: 10.3233/JAD-170969.
Dementia and its first or transitional stage, mild cognitive impairment (MCI), is a major concern for the aging Japanese society. Thus, the use of dietary supplements to improve or maintain cognitive function has become a topic of public interest.
In this study, we evaluated the effects of a composite supplement containing food-derived antioxidants, specifically astaxanthin and sesamin (AS), on cognitive function in people with MCI.
Twenty-one healthy participants with MCI were recruited in our double-blind placebo-controlled pilot study. They were assigned to either an AS group, who received ingestible capsules containing AS, or a placebo group, who received identical placebo capsules. To assess cognitive functions, we performed the Japanese version of the Central Nervous System Vital Signs (CNSVS) test and the Alzheimer's Disease Assessment Scale-Cog test at baseline, after 6 weeks, and after 12 weeks of dietary supplementation.
The CNSVS test revealed significant improvements in psychomotor speed and processing speed in the AS group compared with the placebo group, suggesting that the daily supplementation of AS improved cognitive functions related to the ability to comprehend, and perform complex tasks quickly and accurately.
Our results provide support for the use of AS as a dietary supplementation for improving cognitive functions.
痴呆症及其早期或过渡阶段，即轻度认知障碍（MCI），是日本老龄化社会的主要关注点。因此，使用膳食补充剂来改善或维持认知功能已成为公众关注的话题。
在这项研究中，我们评估了一种含有食物来源抗氧化剂（特别是虾青素和芝麻素）的复合补充剂对 MCI 患者认知功能的影响。
在这项双盲安慰剂对照的初步研究中，我们招募了 21 名健康的 MCI 参与者。他们被分配到虾青素组（AS 组）或安慰剂组（对照组），分别接受含有 AS 的可食用胶囊或相同的安慰剂胶囊。为了评估认知功能，我们在基线、6 周后和 12 周的饮食补充后进行了日本版中枢神经系统生命体征（CNSVS）测试和阿尔茨海默病评估量表-认知测试。
CNSVS 测试显示，与对照组相比，AS 组的精神运动速度和处理速度有显著改善，这表明每日补充 AS 可改善与理解和快速准确执行复杂任务相关的认知功能。
我们的结果支持将 AS 作为改善认知功能的膳食补充剂使用。
