氨基酸的摄取与代谢及其在致病性锥虫生物学中的独特作用。
The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.
作者信息
Marchese Letícia, Nascimento Janaina de Freitas, Damasceno Flávia Silva, Bringaud Frédéric, Michels Paul A M, Silber Ariel Mariano
机构信息
Laboratory of Biochemistry of Tryps-LaBTryps, Department of Parasitology, Institute for Biomedical Sciences, University of Sao Paulo, Av. Lineu Prestes, 1374, São Paulo 05508-000, SP, Brazil.
Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), Université de Bordeaux, CNRS UMR-5234, 146, rue Léo Saignat, Zone Nord, Bâtiment 3A, 33076 Bordeaux, France.
出版信息
Pathogens. 2018 Apr 1;7(2):36. doi: 10.3390/pathogens7020036.
, as well as and more than 20 species of the genus , form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.
以及属的 种和超过20种，构成了一组威胁人类健康的有鞭毛原生生物。这些生物体通过昆虫传播，昆虫与哺乳动物一起是它们的天然宿主。这意味着在它们的生命周期中，每一种生物体都面临着具有不同物理、化学、生化和生物学特征的环境。在这项工作中，我们回顾了氨基酸是如何从这些环境中获取的，它们是如何被代谢的，以及它们和它们的一些中间代谢产物是如何被用作生存工具箱来应对这些寄生虫在昆虫和哺乳动物宿主中建立感染时应面对的不同条件的。
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