Clinical Laboratory, Affiliated Provincial Hospital of Anhui Medical University, 17 Lujiang Road, Hefei, 230001, Anhui, China.
Clinical Laboratory, The Second People's Hospital of Wuhu City, Wuhu, 241001, Anhui, China.
BMC Psychiatry. 2018 Apr 3;18(1):88. doi: 10.1186/s12888-018-1672-4.
Nesfatin-1 plays a role in the regulation of emotional states like depression. The aim of this study was to investigate the plasma nesfatin-1levels in Chinese patients with depression and healthy subjects, and to determine the possible association between the plasma nesfatin-1 level and the severity of depression.
A total of 103 depressive patients and 32 healthy subjects were assessed. According to HAMD-17scores, 51, 18, and 34 patients were enrolled in the mild depression, moderate depression, and severe depression groups, respectively. Plasma nesfatin-1 levels were determined by the ELISA method. Differences between groups were compared and associations between plasma nesfatin-1 and other variables were analyzed.
The plasma nesfatin-1 was significantly positively correlated with HAMD-17 score (r = 0.651). Compared with healthy controls (8.11 ± 3.31 ng/mL), the plasma nesfatin-1 level significantly increased in patients with mild depression (11.17 ± 3.58 ng/mL), with moderate depression (16.33 ± 8.78 ng/mL), and with severe depression (27.65 ± 8.26 ng/mL) respectively. Plasma nesfatin-1 level (Odds ratio [OR] = 1.269) was an independent indicator for severe depression by multivariate logistic regression analysis.
The plasma nesfatin-1 level is positively correlated with the severity of depression. Plasma nesfatin-1 level may be a potential indicator for depression severity.
nesfatin-1 在调节抑郁等情绪状态方面发挥作用。本研究旨在探讨中国抑郁症患者和健康受试者血浆 nesfatin-1 水平，并确定血浆 nesfatin-1 水平与抑郁严重程度的可能相关性。
共评估了 103 例抑郁症患者和 32 例健康受试者。根据 HAMD-17 评分，51、18 和 34 例患者分别纳入轻度抑郁、中度抑郁和重度抑郁组。采用 ELISA 法测定血浆 nesfatin-1 水平。比较组间差异，分析血浆 nesfatin-1 与其他变量的相关性。
血浆 nesfatin-1 与 HAMD-17 评分呈显著正相关（r=0.651）。与健康对照组（8.11±3.31ng/mL）相比，轻度抑郁（11.17±3.58ng/mL）、中度抑郁（16.33±8.78ng/mL）和重度抑郁（27.65±8.26ng/mL）患者的血浆 nesfatin-1 水平显著升高。多元 logistic 回归分析显示，血浆 nesfatin-1 水平（优势比 [OR] = 1.269）是重度抑郁的独立指标。
血浆 nesfatin-1 水平与抑郁严重程度呈正相关。血浆 nesfatin-1 水平可能是评估抑郁严重程度的潜在指标。
