Department of Neurology and Clinical Neurophysiology, Medical Division, Akershus University Hospital, Lørenskog, Norway.
Institute of Clinical Medicine, Campus Akershus University Hospital, University of Oslo, Oslo, Norway.
Sci Rep. 2018 Apr 3;8(1):5579. doi: 10.1038/s41598-018-23904-3.
The purpose of this study was to assess health status (HS) in patients with clinical suspicion of obstructive sleep apnea (OSA) in order to estimate the dose response relationship between HS and OSA severity, and to compare HS in this clinical cohort with a general population sample (N = 5000). Patients referred to an overnight sleep study due to suspected OSA, whom also responded to the SF-36 questionnaire, were included (N = 418). Of these, 194 showed normal findings, while 111, 60 and 53 demonstrated mild, moderate and severe OSA, respectively. Mean age was 47.5 (SD 11.9) and 69% were males. Only the mental health scale (p = 0.015) and mental component summary score (p = 0.023) were associated with OSA severity. This association, however, disappeared in multivariable analysis. All SF-36 scores in the sleep study group were lower than that of the general population sample, in both unadjusted and multivariable linear regression analysis. In this study, there was a lack of association between OSA severity and general HS. However, as a whole, patients in this clinical population referred to an overnight sleep study due to suspected OSA had impaired HS on all scales compared to a general population, with greatest differences in the vitality domain.
本研究旨在评估有临床阻塞性睡眠呼吸暂停（OSA）疑诊的患者的健康状况（HS），以评估 HS 与 OSA 严重程度之间的剂量反应关系，并将该临床队列的 HS 与一般人群样本（N=5000）进行比较。纳入因疑似 OSA 而接受整夜睡眠研究且对 SF-36 问卷做出回应的患者（N=418）。其中 194 例结果正常，111 例、60 例和 53 例分别显示为轻度、中度和重度 OSA。平均年龄为 47.5（标准差 11.9），69%为男性。仅心理健康量表（p=0.015）和心理成分综合评分（p=0.023）与 OSA 严重程度相关。然而，在多变量分析中，这种关联消失了。在未调整和多变量线性回归分析中，睡眠研究组的所有 SF-36 评分均低于一般人群样本。在这项研究中，OSA 严重程度与一般 HS 之间缺乏关联。然而，作为一个整体，因疑似 OSA 而接受整夜睡眠研究的临床人群患者的所有 HS 评分均低于一般人群，其中活力域的差异最大。
