Reglodi Dora, Illes Anita, Opper Balazs, Schafer Eszter, Tamas Andrea, Horvath Gabriella
Department of Anatomy, MTA-PTE PACAP Research Team, Centre for Neuroscience, University of Pecs Medical School, Pecs, Hungary.
1st Department of Internal Medicine, University of Pecs Medical School, Pecs, Hungary.
Front Endocrinol (Lausanne). 2018 Mar 19;9:90. doi: 10.3389/fendo.2018.00090. eCollection 2018.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide with widespread occurrence throughout the body including the gastrointestinal system. In the small and large intestine, effects of PACAP on cell proliferation, secretion, motility, gut immunology and blood flow, as well as its importance in bowel inflammatory reactions and cancer development have been shown and reviewed earlier. However, no current review is available on the actions of PACAP in the stomach in spite of numerous data published on the gastric presence and actions of the peptide. Therefore, the aim of the present review is to summarize currently available data on the distribution and effects of PACAP in the stomach. We review data on the localization of PACAP and its receptors in the stomach wall of various mammalian and non-mammalian species, we then give an overview on PACAP's effects on secretion of gastric acid and various hormones. Effects on cell proliferation, differentiation, blood flow and gastric motility are also reviewed. Finally, we outline PACAP's involvement and changes in various human pathological conditions.
垂体腺苷酸环化酶激活多肽（PACAP）是一种多功能神经肽，广泛分布于包括胃肠道系统在内的全身各处。在小肠和大肠中，PACAP对细胞增殖、分泌、运动、肠道免疫和血流的影响，以及其在肠道炎症反应和癌症发展中的重要性，此前已有相关研究和综述。然而，尽管已经发表了大量关于该肽在胃中的存在和作用的数据，但目前尚无关于PACAP在胃中作用的综述。因此，本综述的目的是总结目前关于PACAP在胃中的分布和作用的现有数据。我们回顾了关于PACAP及其受体在各种哺乳动物和非哺乳动物胃壁中的定位数据，然后概述了PACAP对胃酸和各种激素分泌的影响。还综述了其对细胞增殖、分化、血流和胃动力的影响。最后，我们概述了PACAP在各种人类病理状况中的参与情况和变化。
