Yadav Amit S, Pandey Poonam R, Butti Ramesh, Radharani N N V, Roy Shamayita, Bhalara Shaileshkumar R, Gorain Mahadeo, Kundu Gopal C, Kumar Dhiraj
Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Pune, India.
Laboratory of Genetics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.
Front Oncol. 2018 Mar 19;8:72. doi: 10.3389/fonc.2018.00072. eCollection 2018.
Advancements in the early detection of cancer coupled with improved surgery, radiotherapy, and adjuvant therapy led to substantial increase in patient survival. Nevertheless, cancer metastasis is the leading cause of death in several cancer patients. The majority of these deaths are associated with metastatic relapse kinetics after a variable period of clinical remission. Most of the cancer recurrences are thought to be associated with the reactivation of dormant disseminated tumor cells (DTCs). In this review, we have summarized the cellular and molecular mechanisms related to DTCs and the role of microenvironmental niche. These mechanisms regulate the dormant state and help in the reactivation, which leads to metastatic outgrowth. Identification of novel therapeutic targets to eliminate these dormant tumor cells will be highly useful in controlling the metastatic relapse-related death with several cancers.
癌症早期检测技术的进步，再加上手术、放疗和辅助治疗的改进，使得患者生存率大幅提高。然而，癌症转移是导致部分癌症患者死亡的主要原因。这些死亡中的大多数与临床缓解一段时间后的转移性复发动力学有关。大多数癌症复发被认为与休眠播散肿瘤细胞（DTCs）的重新激活有关。在这篇综述中，我们总结了与DTCs相关的细胞和分子机制以及微环境生态位的作用。这些机制调节休眠状态并有助于重新激活，从而导致转移灶生长。识别消除这些休眠肿瘤细胞的新治疗靶点对于控制多种癌症的转移性复发相关死亡将非常有用。
