Schoenwolf Gary C
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Int J Dev Biol. 2018;62(1-2-3):49-55. doi: 10.1387/ijdb.170288gs.
The chick embryo has served as a workhorse for experimental embryological studies designed to elucidate mechanisms underlying neurulation, the process that forms the neural tube, the rudiment of the entire adult central nervous system. Early chick embryos developing in whole-embryo culture can be readily manipulated in cut-and-paste-type experiments, and this attribute makes this model system unparalleled for studying the morphogenesis of embryos and their organ rudiments. How the chick embryo and experimental embryology have contributed to our understanding of critical events of neurulation are summarized.
鸡胚一直是实验胚胎学研究的主力军，这类研究旨在阐明神经胚形成过程（即形成神经管，整个成体中枢神经系统原基的过程）背后的机制。在全胚胎培养中发育的早期鸡胚，在类似“剪切和粘贴”的实验中很容易进行操作，这一特性使得该模型系统在研究胚胎及其器官原基的形态发生方面无与伦比。本文总结了鸡胚和实验胚胎学如何促进了我们对神经胚形成关键事件的理解。
