Gandhi Shashank, Bronner Marianne E
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.
Int J Dev Biol. 2018;62(1-2-3):183-194. doi: 10.1387/ijdb.180038sg.
The neural crest is a multipotent and highly migratory cell type that contributes to many of the defining features of vertebrates, including the skeleton of the head and most of the peripheral nervous system. 150 years after the discovery of the neural crest, avian embryos remain one of the most important model organisms for studying neural crest development. In this review, we describe aspects of neural crest induction, migration and axial level differences, highlighting what is known about the underlying gene regulatory mechanisms. Past and emerging technologies continue to improve the resolution with which we can examine important questions of neural crest development, with modern avian molecular embryology continuing to make important contributions.
神经嵴是一种多能且高度迁移的细胞类型，它对脊椎动物的许多标志性特征都有贡献，包括头部骨骼和大部分外周神经系统。在神经嵴被发现150年后，鸟类胚胎仍然是研究神经嵴发育最重要的模式生物之一。在这篇综述中，我们描述了神经嵴诱导、迁移和轴向水平差异的各个方面，突出了关于潜在基因调控机制的已知内容。过去和新兴技术不断提高我们研究神经嵴发育重要问题的分辨率，现代鸟类分子胚胎学继续做出重要贡献。
