Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110122, China.
Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Province Department of Education, Shenyang 110122, China.
Molecules. 2018 Apr 4;23(4):832. doi: 10.3390/molecules23040832.
Lung cancer is the principal cause of cancer-associated deaths. has been reported to be associated with tumorigenesis. This study aimed to investigate the relationship between rs1412125 and rs1360485 polymorphisms in and the risk and survival of lung cancer. 850 cases and 733 controls were included. Logistic regression analysis and survival analysis were performed to investigate the association between SNPs and the risk and survival of lung cancer. Crossover analysis was used to analyze the interaction between SNPs and tobacco exposure. Results indicated that rs1412125 polymorphism was associated with lung cancer risk, especially with the risk of lung adenocarcinoma and small cell lung cancer. Carriers with CT and CC genotypes had a decreased risk of lung cancer (CT + CC vs.TT: adjusted OR = 0.736, = 0.004). Similar results were obtained in the stratification analysis for non-smokers and female population. For rs1360485 polymorphism, AG and GG genotypes could decrease the risk of lung adenocarcinoma and female lung cancer by 0.771-fold and 0.789-fold. However, no significant interaction between polymorphisms and tobacco exposure or association between SNPs and the survival of lung cancer was observed. This study indicated polymorphisms in may be a novel biomarker for female lung adenocarcinoma risk.
肺癌是癌症相关死亡的主要原因。已经有报道称与肿瘤发生有关。本研究旨在探讨 rs1412125 和 rs1360485 多态性与肺癌的风险和生存之间的关系。纳入了 850 例病例和 733 例对照。进行了 logistic 回归分析和生存分析，以探讨 SNP 与肺癌风险和生存之间的关系。交叉分析用于分析 SNP 与烟草暴露之间的相互作用。结果表明，rs1412125 多态性与肺癌风险相关，尤其是与肺腺癌和小细胞肺癌的风险相关。CT 和 CC 基因型携带者患肺癌的风险降低（CT + CC 与 TT：调整 OR = 0.736， = 0.004）。在非吸烟者和女性人群的分层分析中也得到了类似的结果。对于 rs1360485 多态性，AG 和 GG 基因型可使肺腺癌和女性肺癌的风险分别降低 0.771 倍和 0.789 倍。然而，未观察到多态性与烟草暴露之间的显著交互作用，也未观察到 SNP 与肺癌生存之间的关联。本研究表明， 中的多态性可能是女性肺腺癌风险的一个新的生物标志物。
