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[高甘油三酯血症腰围表型:ELSA-Brasil研究中的相关因素及与其他心血管和代谢风险指标的比较]

[Hypertriglyceridemic waist phenotype: associated factors and comparison with other cardiovascular and metabolic risk indicators in the ELSA-Brasil study].

作者信息

Freitas Roberta Souza, Fonseca Maria de Jesus Mendes da, Schmidt Maria Inês, Molina Maria Del Carmen Bisi, Almeida Maria da Conceição Chagas de

机构信息

Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Brasil.

Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

出版信息

Cad Saude Publica. 2018 Mar 29;34(4):e00067617. doi: 10.1590/0102-311X00067617.

DOI:10.1590/0102-311X00067617
PMID:29617485
Abstract

This study's objectives were to estimate the prevalence of hypertriglyceridemic waist (HTW) phenotype in participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), identify associated risk factors, and compare with other cardiovascular and metabolic risk indicators. This was a cross-sectional study with baseline data from a cohort of public employees. HTW is defined as the simultaneous presence of increased waist circumference (WC) (≥ 80cm for women, ≥ 90cm for men according to the International Diabetes Federation - IDF; and ≥ 88cm for women, ≥ 102cm for men according to the U.S. National Cholesterol Education Program - NCEP) and hypertriglyceridemia. Associations between independent variables and HTW were tested with multivariate logistic regression models. HTW was also compared to other cardiovascular and metabolic risk indicators by means of correlation tests, kappa index, sensitivity, and specificity. After exclusions, 12,811 participants were analyzed. Prevalence of HTW ranged from 24.7% (IDF) to 13.3% (NCEP). HTW was associated with age, excessive alcohol consumption, former smoking, low HDL, non-high HDL, and increased C-reactive protein, independently of gender or the criterion used to define HTW. HTW was associated with cardiovascular risk indicators, especially metabolic syndrome. The high prevalence of HTW and its association with cardiovascular risk indicators, especially metabolic syndrome, supports its use as a cardiometabolic risk screening tool in clinical practice.

摘要

本研究的目的是估计巴西成人健康纵向研究(ELSA-Brasil)参与者中高甘油三酯血症腰围(HTW)表型的患病率,识别相关风险因素,并与其他心血管和代谢风险指标进行比较。这是一项基于公职人员队列基线数据的横断面研究。HTW定义为同时存在腰围增加(根据国际糖尿病联盟 - IDF,女性≥80cm,男性≥90cm;根据美国国家胆固醇教育计划 - NCEP,女性≥88cm,男性≥102cm)和高甘油三酯血症。使用多变量逻辑回归模型检验自变量与HTW之间的关联。还通过相关性检验、kappa指数、敏感性和特异性将HTW与其他心血管和代谢风险指标进行比较。排除后,对12,811名参与者进行了分析。HTW的患病率在24.7%(IDF)至13.3%(NCEP)之间。HTW与年龄、过量饮酒、既往吸烟、低高密度脂蛋白、非高密度脂蛋白以及C反应蛋白升高相关,与性别或用于定义HTW的标准无关。HTW与心血管风险指标相关,尤其是代谢综合征。HTW的高患病率及其与心血管风险指标(尤其是代谢综合征)的关联,支持将其用作临床实践中的心脏代谢风险筛查工具。

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