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本文引用的文献

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Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins.全细胞癌疫苗可诱导针对碳水化合物和糖蛋白产生大量抗体反应。
Cell Chem Biol. 2016 Dec 22;23(12):1515-1525. doi: 10.1016/j.chembiol.2016.10.012. Epub 2016 Nov 23.
2
Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions.黏蛋白与包括MUC1在内的Tn或唾液酸化Tn癌症抗原之间的相互作用是由N-乙酰半乳糖胺- N-乙酰半乳糖胺相互作用引起的。
Glycobiology. 2016 Dec;26(12):1338-1350. doi: 10.1093/glycob/cww065. Epub 2016 Jun 9.
3
Many Light Touches Convey the Message.许多轻触传达信息。
Trends Biochem Sci. 2015 Nov;40(11):673-686. doi: 10.1016/j.tibs.2015.08.010. Epub 2015 Oct 1.
4
The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.与乳腺癌相关的MUC1、MUC1-Tn和唾液酸化Tn糖型在COSMC野生型细胞中表达，并与C型凝集素MGL结合。
PLoS One. 2015 May 7;10(5):e0125994. doi: 10.1371/journal.pone.0125994. eCollection 2015.
5
Protein glycosylation in cancer.癌症中的蛋白质糖基化
Annu Rev Pathol. 2015;10:473-510. doi: 10.1146/annurev-pathol-012414-040438.
6
GM3 and cancer.GM3与癌症。
Glycoconj J. 2015 Feb;32(1-2):1-8. doi: 10.1007/s10719-014-9572-4. Epub 2015 Jan 23.
7
A red meat-derived glycan promotes inflammation and cancer progression.一种源自红肉的聚糖会促进炎症和癌症进展。
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):542-7. doi: 10.1073/pnas.1417508112. Epub 2014 Dec 29.
8
Single molecule study of heterotypic interactions between mucins possessing the Tn cancer antigen.对具有Tn癌抗原的黏蛋白之间异型相互作用的单分子研究。
Glycobiology. 2015 May;25(5):524-34. doi: 10.1093/glycob/cwu183. Epub 2014 Dec 19.
9
Immature truncated O-glycophenotype of cancer directly induces oncogenic features.癌症不成熟的截短型O-糖表型直接诱导致癌特征。
Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12.
10
Mucins: a biologically relevant glycan barrier in mucosal protection.黏蛋白：黏膜保护中具有生物学相关性的聚糖屏障。
Biochim Biophys Acta. 2015 Jan;1850(1):236-52. doi: 10.1016/j.bbagen.2014.05.003. Epub 2014 May 10.

Tn 和 STn 是糖脂肿瘤抗原家族的成员，具有糖-糖相互作用。

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions.

机构信息

Department of Biotechnology and Food Science, NTNU The Norwegian University of Science and Technology, Trondheim, Norway.

Departments of Pediatrics and Biochemistry, W. A. Bernbaum Center for Cystic Fibrosis Research, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

出版信息

Glycobiology. 2018 Jul 1;28(7):437-442. doi: 10.1093/glycob/cwy032.

DOI:10.1093/glycob/cwy032
PMID:29618060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6001880/
Abstract

The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.

摘要

癌症中的黏蛋白型 O-聚糖异常表达截断聚糖 Tn（GalNAcα1-Ser/Thr）和 STn（Neu5Acα2,6GalNAcα1-Ser/Thr）。然而，Tn 和 STn 在癌症和其他疾病中的作用尚未完全了解。我们最近发现 Tn（Tn-Tn）和 STn（STn-STn）的自结合特性（碳水化合物-碳水化合物相互作用，CCIs）为它们在细胞转化中的可能作用提供了模型。我们还回顾了证据表明 Tn 和 STn 是具有 CCIs 的更大糖抗原肿瘤抗原家族的成员，它们可能参与肿瘤发生。