多能干细胞的心脏分化及其在健康和疾病中心脏建模中的意义。
Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease.
机构信息
Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZC Leiden, Netherlands.
Department of Applied Stem Cell Technologies, Technical Medical Center, University of Twente, 7500 AE Enschede, Netherlands.
出版信息
Sci Transl Med. 2018 Apr 4;10(435). doi: 10.1126/scitranslmed.aah5457.
Cellular models comprising cardiac cell types derived from human pluripotent stem cells are valuable for studying heart development and disease. We discuss transcriptional differences that define cellular identity in the heart, current methods for generating different cardiomyocyte subtypes, and implications for disease modeling, tissue engineering, and regenerative medicine.
包含源自人类多能干细胞的心脏细胞类型的细胞模型对于研究心脏发育和疾病非常有价值。我们讨论了定义心脏细胞特性的转录差异、目前生成不同心肌细胞亚型的方法，以及这些方法在疾病建模、组织工程和再生医学方面的意义。
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