• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卵泡抑素过表达的代谢谱分析：一种治疗代谢性疾病的新策略。

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.

作者信息

Singh Rajan, Pervin Shehla, Lee Se-Jin, Kuo Alan, Grijalva Victor, David John, Vergnes Laurent, Reddy Srinivasa T

机构信息

Department of Obstetrics and Gynecology, UCLA School of Medicine, Los Angeles, CA, USA.

Division of Endocrinology and Metabolism, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.

出版信息

Diabetes Metab Syndr Obes. 2018 Mar 26;11:65-84. doi: 10.2147/DMSO.S159315. eCollection 2018.

DOI:10.2147/DMSO.S159315
PMID:29618935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5875402/
Abstract

BACKGROUND

Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues.

METHODS

Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3-L1 cells.

RESULTS

Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice. Furthermore, overexpression of Fst in 3T3-L1 cells resulted in up regulation of key brown/beige markers and changes in lipidomics profiles.

CONCLUSION

Fst modulates key factors involved in promoting metabolic syndrome and could be used for therapeutic intervention.

摘要

背景

卵泡抑素（Fst）可促进脂肪组织中棕色脂肪细胞的特性。

方法

对Fst转基因（Fst-Tg）小鼠和野生型（WT）对照小鼠的腹部脂肪体积（CT扫描）、葡萄糖清除率（葡萄糖耐量试验）以及脂肪组织的代谢组学分析（质谱分析）进行了研究。使用海马分析仪对3T3-L1细胞的耗氧量进行了分析，并采用气相色谱法进行了脂质组学分析。

结果

与WT小鼠相比，Fst-Tg小鼠的腹部脂肪含量显著降低，葡萄糖清除率提高，血浆脂质谱改善，几种传统代谢物也发生了显著变化。此外，在3T3-L1细胞中过表达Fst导致关键棕色/米色标志物上调以及脂质组学谱的改变。

结论

Fst可调节参与促进代谢综合征的关键因素，可用于治疗干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/2f257922dc93/dmso-11-065Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/fe91b8a2b4c2/dmso-11-065Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/5d354013242f/dmso-11-065Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/a25136b3fd69/dmso-11-065Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/0bc54e7ff1dc/dmso-11-065Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/2f257922dc93/dmso-11-065Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/fe91b8a2b4c2/dmso-11-065Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/5d354013242f/dmso-11-065Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/a25136b3fd69/dmso-11-065Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/0bc54e7ff1dc/dmso-11-065Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d046/5875402/2f257922dc93/dmso-11-065Fig5.jpg

相似文献

1
Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.卵泡抑素过表达的代谢谱分析：一种治疗代谢性疾病的新策略。
Diabetes Metab Syndr Obes. 2018 Mar 26;11:65-84. doi: 10.2147/DMSO.S159315. eCollection 2018.
2
Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.卵泡抑素通过靶向不同途径促进棕色和白色脂肪组织中的棕色脂肪细胞特性。
Endocrinology. 2017 May 1;158(5):1217-1230. doi: 10.1210/en.2016-1607.
3
Follistatin promotes adipocyte differentiation, browning, and energy metabolism.卵泡抑素促进脂肪细胞分化、棕色化和能量代谢。
J Lipid Res. 2014 Mar;55(3):375-84. doi: 10.1194/jlr.M039719. Epub 2014 Jan 17.
4
Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders.卵泡抑素/肌肉生长抑制素在转化生长因子-β信号转导和脂肪褐变中的新作用：在肥胖相关代谢紊乱的治疗干预中的潜力。
Front Endocrinol (Lausanne). 2021 Apr 9;12:653179. doi: 10.3389/fendo.2021.653179. eCollection 2021.
5
Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.脂肪细胞特异性缺氧诱导因子 2 促进脂肪沉积和饮食诱导的胰岛素抵抗。
Mol Metab. 2016 Sep 28;5(12):1149-1161. doi: 10.1016/j.molmet.2016.09.009. eCollection 2016 Dec.
6
Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice.腹腔内给予卵泡抑素可促进高脂肪饮食诱导肥胖小鼠的脂肪细胞棕色化。
PLoS One. 2019 Jul 31;14(7):e0220310. doi: 10.1371/journal.pone.0220310. eCollection 2019.
7
Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity.脂肪组织中骨形态发生蛋白-3b（BMP-3b）的过表达可预防高脂饮食诱导的肥胖。
Int J Obes (Lond). 2017 Apr;41(4):483-488. doi: 10.1038/ijo.2017.15. Epub 2017 Jan 20.
8
Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype.脂肪组织过表达 perilipin 可诱导形成棕色脂肪样表型。
PLoS One. 2010 Nov 16;5(11):e14006. doi: 10.1371/journal.pone.0014006.
9
Follistatin and follistatin like-3 differentially regulate adiposity and glucose homeostasis.卵泡抑素和卵泡抑素样蛋白 3 可差异调节脂肪量和葡萄糖稳态。
Obesity (Silver Spring). 2011 Oct;19(10):1940-9. doi: 10.1038/oby.2011.97. Epub 2011 May 5.
10
Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis.成纤维细胞生长因子 21 衍生肽在肌肉中的表达可减少脂肪组织质量并防止肝脂肪变性。
Am J Physiol Endocrinol Metab. 2011 Mar;300(3):E543-53. doi: 10.1152/ajpendo.00430.2010. Epub 2011 Jan 4.

引用本文的文献

1
Activin Actions in Adipocytes.激活素在脂肪细胞中的作用。
J Clin Endocrinol Metab. 2025 Jun 17;110(7):1803-1810. doi: 10.1210/clinem/dgaf233.
2
The Effect of Exercise on Spexin and Follistatin in Elderly Individuals.运动对老年人中spexin和卵泡抑素的影响。
J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13692. doi: 10.1002/jcsm.13692.
3
Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males.探讨虾青素补充与 12 周交叉健身训练方案相结合对肥胖男性选定脂肪-肌肉因子水平的影响。

本文引用的文献

1
Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions.驯服火焰：靶向代谢亢进状态下的白色脂肪组织棕色化。
Endocr Rev. 2017 Dec 1;38(6):538-549. doi: 10.1210/er.2017-00163.
2
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice.在小鼠从轻度到重度冷适应过程中，棕色脂肪组织和骨骼肌的产热过程均被激活。
J Biol Chem. 2017 Oct 6;292(40):16616-16625. doi: 10.1074/jbc.M117.790451. Epub 2017 Aug 9.
3
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Nutrients. 2024 Aug 26;16(17):2857. doi: 10.3390/nu16172857.
4
Population-scale skeletal muscle single-nucleus multi-omic profiling reveals extensive context specific genetic regulation.群体规模的骨骼肌单核多组学分析揭示了广泛的上下文特异性基因调控。
bioRxiv. 2024 Dec 17:2023.12.15.571696. doi: 10.1101/2023.12.15.571696.
5
The role of hepatokines in NAFLD.肝分泌物在非酒精性脂肪性肝病中的作用。
Cell Metab. 2023 Feb 7;35(2):236-252. doi: 10.1016/j.cmet.2023.01.006.
6
Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance.骨骼肌肌因子改善胰岛素抵抗的机制。
Int J Mol Sci. 2022 Apr 22;23(9):4636. doi: 10.3390/ijms23094636.
7
Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders.卵泡抑素/肌肉生长抑制素在转化生长因子-β信号转导和脂肪褐变中的新作用：在肥胖相关代谢紊乱的治疗干预中的潜力。
Front Endocrinol (Lausanne). 2021 Apr 9;12:653179. doi: 10.3389/fendo.2021.653179. eCollection 2021.
8
Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People.不同运动方案对健康人群运动诱导细胞因子的影响。
Int J Environ Res Public Health. 2021 Jan 31;18(3):1261. doi: 10.3390/ijerph18031261.
9
Hepatokines as a Molecular Transducer of Exercise.肝源细胞因子作为运动的分子转导器
J Clin Med. 2021 Jan 20;10(3):385. doi: 10.3390/jcm10030385.
10
Mechanisms involved in follistatin-induced hypertrophy and increased insulin action in skeletal muscle.在骨骼肌中，成纤维细胞生长因子 21 诱导的肌肥大和胰岛素作用增强的机制。
J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1241-1257. doi: 10.1002/jcsm.12474. Epub 2019 Aug 11.
脂肪细胞mTORC1缺乏通过氧化应激和从头神经酰胺合成促进脂肪组织炎症和NLRP3炎性小体激活。
J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5.
4
AMP-activated protein kinase, fatty acid metabolism, and insulin sensitivity.AMP激活的蛋白激酶、脂肪酸代谢与胰岛素敏感性
Curr Opin Clin Nutr Metab Care. 2017 Jul;20(4):248-253. doi: 10.1097/MCO.0000000000000380.
5
Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues.卵泡抑素通过靶向不同途径促进棕色和白色脂肪组织中的棕色脂肪细胞特性。
Endocrinology. 2017 May 1;158(5):1217-1230. doi: 10.1210/en.2016-1607.
6
Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides.高脂饮食诱导的小鼠肥胖的脂质组学分析：细胞色素P450衍生的脂肪酸环氧化物的重要性。
Obesity (Silver Spring). 2017 Jan;25(1):132-140. doi: 10.1002/oby.21692. Epub 2016 Nov 28.
7
Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling.热量限制通过 2 型免疫信号导致白色脂肪组织的褐色化。
Cell Metab. 2016 Sep 13;24(3):434-446. doi: 10.1016/j.cmet.2016.07.023. Epub 2016 Aug 25.
8
Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378.二十碳五烯酸通过FFAR4依赖性上调miR-30b和miR-378增强棕色脂肪产热。
J Biol Chem. 2016 Sep 23;291(39):20551-62. doi: 10.1074/jbc.M116.721480. Epub 2016 Aug 3.
9
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.脂肪细胞中缺乏AMPK会通过棕色和米色脂肪组织功能加剧胰岛素抵抗和肝脏脂肪变性。
Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006.
10
Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health.代谢组学分析以剖析内脏脂肪在心脏代谢健康中的作用。
Obesity (Silver Spring). 2016 Jun;24(6):1380-8. doi: 10.1002/oby.21488. Epub 2016 Apr 30.