Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Front Immunol. 2018 Mar 21;9:598. doi: 10.3389/fimmu.2018.00598. eCollection 2018.
Antigens in particulate form have distinct immunologic properties relative to soluble antigens. An understanding of the mechanisms and functional consequences of the distinct immunologic pathways engaged by these different forms of antigen is particularly relevant to the design of vaccines. It is also relevant regarding the use of therapeutic human proteins in clinical medicine that have been shown to aggregate, and perhaps as a result, elicit autoantibodies.
颗粒状抗原相对于可溶性抗原具有独特的免疫学特性。了解这些不同形式的抗原所涉及的独特免疫途径的机制和功能后果，对于疫苗的设计特别重要。对于在临床医学中使用已经被证明会聚集的治疗性人类蛋白，并且可能因此引发自身抗体的情况，这也是相关的。
