Anselmo Lima Carlos, Sampaio Lima Marcela, Maria Da Silva Angela, Prado Nunes Marco Antonio, Macedo Lima Marcia Maria, Oliveira Santos Marceli, Lyra Divaldo, Kleber Alves Carlos
Aracaju Cancer Registry, Tancredo Neves Avenue, Capucho. 49010-460, Aracaju, SE, Brazil, Oncology Unit/HUSE/SES, Tancredo Neves Avenue, Capucho. 49010-460, Aracaju, SE, Brazil, University Hospital/Federal University of Sergipe/EBSERH, Claudio Batista Street, Santo Antonio. 49060-108, Aracaju, SE, Brazil.
University Hospital/Federal University of Sergipe/EBSERH, Claudio Batista Street, Santo Antonio. 49060-108, Aracaju, SE, Brazil.
Eur J Dermatol. 2018 Apr 1;28(2):169-176. doi: 10.1684/ejd.2018.3248.
Non-melanoma skin cancers have the highest incidence of all malignancies worldwide. However, cancer registries rarely include data on non-melanoma skin cancers because they tend to be under-reported. To determine incidence rates and changes over time for non-melanoma skin cancers in a mid-sized Brazilian population. We calculated age-standardized rates, adjusted to the world population using the direct method, from 1996-2012 in the Aracaju Cancer Registry and then calculated incidence trends using the Joinpoint Regression Program. We analysed 11,476 cases (5,695 men and 5,781 women) of non-melanoma skin cancer collected during the study period. The histological subtypes in men were 84.5% basal cell carcinoma, 14.5% squamous cell carcinoma, and 1% other histological subtypes, whereas the corresponding percentages in women were 89.1%, 10%, and 0.9%, respectively. Average incidence age-standardized rates were 228.6 (95% CI: 221.6; 235.6) per 100,000 men and 145.4 (95% CI: 141.0; 149.9) per 100,000 women. The incidence mostly increased in the first years for the series and then stabilized. The under-reporting of non-melanoma skin cancers, due to removal of lesions without histopathological confirmation, decisions to keep skin lesions under observation instead of excising them, and deferring medical examination, is a potential pitfall of this study. Age-standardized incidence of non-melanoma skin cancer was high during the study period, but tended to stabilise in the latter years of the study.
非黑色素瘤皮肤癌在全球所有恶性肿瘤中发病率最高。然而，癌症登记处很少纳入非黑色素瘤皮肤癌的数据，因为这类癌症往往报告不足。为了确定巴西一个中等规模人群中非黑色素瘤皮肤癌的发病率及随时间的变化情况。我们采用直接法，根据阿拉卡茹癌症登记处1996年至2012年的数据，计算了年龄标准化发病率，并将其调整为世界人口的发病率，然后使用Joinpoint回归程序计算发病率趋势。我们分析了研究期间收集的11476例非黑色素瘤皮肤癌病例（5695名男性和5781名女性）。男性的组织学亚型中，基底细胞癌占84.5%，鳞状细胞癌占14.5%，其他组织学亚型占1%；而女性相应的百分比分别为89.1%、10%和0.9%。年龄标准化平均发病率为每10万名男性228.6（95%置信区间：221.6；235.6），每10万名女性145.4（95%置信区间：141.0；149.9）。该系列发病率在最初几年大多呈上升趋势，随后趋于稳定。由于在没有组织病理学确认的情况下切除病变、决定对皮肤病变进行观察而非切除以及推迟医学检查，导致非黑色素瘤皮肤癌报告不足，这是本研究的一个潜在缺陷。在研究期间，非黑色素瘤皮肤癌的年龄标准化发病率较高，但在研究后期趋于稳定。
