a Laboratorio de Desarrollo Analítico y Control de Procesos , CIDQ, Instituto Nacional de Tecnología Industrial , Buenos Aires , Argentina.
b Instituto de Recursos Biológicos , CIRN. Instituto Nacional de Tecnología Agropecuaria , Buenos Aires , Argentina.
Nat Prod Res. 2019 Sep;33(17):2574-2578. doi: 10.1080/14786419.2018.1460826. Epub 2018 Apr 5.
Several species are widely used in Southern South America in the treatment of infections, pain and several diseases including diabetes. Flavonoid compounds based on quercetin and kaempferol glycoside derivatives are believed to be responsible for their therapeutic properties. To investigate this, we have studied two native species from Argentina: (BU) and subsp. (BF). We have analyzed the major polyphenol components in hydro-methanolic extracts of leaves, by high performance liquid chromatography tandem mass spectrometry. Chromatographic analysis yielded five main compounds in BF, corresponding to rutinosides and rhamnosides derivatives of kaempferol and quercetin, which are considered chemotaxonomic markers and responsible for antioxidant activity. The presence of kaempferitrin, an antidiabetic agent, has been confirmed. In extracts of BU, four major compounds were identified as rhamnosides and galloyl derivates from quercetin and kaempferol. One of these compounds, quercitrin-3-rhamnoside may confer anti-inflammatory and analgesic properties to BU extracts.
几种物种在南美洲南部被广泛用于治疗感染、疼痛和包括糖尿病在内的几种疾病。基于槲皮素和山柰酚糖苷衍生物的类黄酮化合物被认为是其治疗特性的原因。为了研究这一点，我们研究了来自阿根廷的两个本地物种：（BU）和亚种。（BF）。我们通过高效液相色谱串联质谱法分析了叶用水-甲醇提取物中的主要多酚成分。色谱分析在 BF 中产生了五种主要化合物，对应于山柰酚和槲皮素的芸香糖苷和鼠李糖苷衍生物，这些化合物被认为是化学分类标记物，负责抗氧化活性。已经证实了存在抗糖尿病剂山奈酚配基。在 BU 的提取物中，鉴定出四种主要化合物为槲皮素和山柰酚的鼠李糖苷和没食子酰衍生物。其中一种化合物，槲皮素-3-鼠李糖苷可能使 BU 提取物具有抗炎和镇痛特性。
