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乳酸脱氢酶-A和-D亚基在人子宫肌瘤和子宫肉瘤中的表达及预后价值

Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma.

作者信息

Song Ke-Juan, Yu Xiao-Ni, Lv Teng, Chen Yu-Long, Diao Yu-Chao, Liu Su-Li, Wang Yan-Kui, Yao Qin

机构信息

Department of Gynecology, the Affiliated Hospital of Qingdao University, 1677 Wutai Mountain Road, Huangdao District, Qingdao City, Shandong Province, China Department of Gynecology, the Ninth People's Hospital of Qingdao,shinan District, Qingdao City, Shandong Province, China.

出版信息

Medicine (Baltimore). 2018 Apr;97(14):e0268. doi: 10.1097/MD.0000000000010268.

DOI:10.1097/MD.0000000000010268
PMID:29620641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5902263/
Abstract

OBJECTIVE

This study aimed to determine the expression of lactate dehydrogenase (LDH)-A and LDH-D in patients with uterine myoma, cellular leiomyoma (CLM), and uterine sarcoma and to evaluate their prognostic significance.

METHODS

Protein expression levels of LDH-A and LDH-D were determined in tissue samples from 86 patients (26 uterine myoma, 10 CLM, 50 uterine sarcoma) by immunohistochemistry and their associations with clinicopathologic parameters and outcomes were analyzed in patients with uterine sarcoma.

RESULTS

The positivity rates for LDH-A and LDH-D were significantly higher in patients with uterine sarcoma compared with those with uterine myoma or CLM (P < .05). Patients with uterine sarcoma were classified as having uterine leiomyosarcoma (LMS), malignant endometrial stromal sarcoma, and malignant mixed Mullerian tumor, with 5-year overall survival rates of 59%, 71%, and 29%, respectively (P < .05). Univariate analysis showed that patients younger than 50 years and with stage I-II had better clinical prognoses. LDH-A-positive LMS patients had a poorer prognosis than LDH-A-negative patients (P = .03). The median survival time of LDH-A-positive patients was 35 months.

CONCLUSIONS

We demonstrated that LDH-D was expressed in patients with uterine sarcoma. Furthermore, the overexpressions of LDH-A and LDH-D in uterine sarcoma patients may contribute to further understanding of the mechanism of LDH in tumor metabolism in uterine sarcoma. Positive expression of LDH-A in patients with LMS may act as a potential prognostic biomarker in these patients.

摘要

目的

本研究旨在确定乳酸脱氢酶（LDH）-A和LDH-D在子宫肌瘤、细胞性平滑肌瘤（CLM）及子宫肉瘤患者中的表达情况，并评估其预后意义。

方法

采用免疫组织化学法检测86例患者（26例子宫肌瘤、10例CLM、50例子宫肉瘤）组织样本中LDH-A和LDH-D的蛋白表达水平，并分析子宫肉瘤患者中其与临床病理参数及预后的相关性。

结果

与子宫肌瘤或CLM患者相比，子宫肉瘤患者中LDH-A和LDH-D的阳性率显著更高（P<0.05）。子宫肉瘤患者分为子宫平滑肌肉瘤（LMS）、恶性子宫内膜间质肉瘤和恶性米勒管混合瘤，其5年总生存率分别为59%、71%和29%（P<0.05）。单因素分析显示，年龄小于50岁且处于I-II期的患者临床预后较好。LDH-A阳性的LMS患者预后较LDH-A阴性患者差（P = 0.03）。LDH-A阳性患者的中位生存时间为35个月。

结论

我们证明LDH-D在子宫肉瘤患者中表达。此外，子宫肉瘤患者中LDH-A和LDH-D的过表达可能有助于进一步了解LDH在子宫肉瘤肿瘤代谢中的机制。LMS患者中LDH-A的阳性表达可能作为这些患者潜在的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/1b941adfd7e3/medi-97-e0268-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/0f68412ad6ea/medi-97-e0268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/db18403f9ebc/medi-97-e0268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/84ac34184885/medi-97-e0268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/1b941adfd7e3/medi-97-e0268-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/0f68412ad6ea/medi-97-e0268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/db18403f9ebc/medi-97-e0268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/84ac34184885/medi-97-e0268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fcd3/5902263/1b941adfd7e3/medi-97-e0268-g008.jpg

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